(Q54457318)

30 May 2018

title

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. (English)

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30 May 2018

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K Miura

1

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30 May 2018

Y Wakayama

2

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30 May 2018

M Tanino

3

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30 May 2018

Y Orba

4

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30 May 2018

H Sawa

5

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30 May 2018

M Hatakeyama

6

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30 May 2018

S Tanaka

7

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30 May 2018

H Sabe

8

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30 May 2018

N Mochizuki

9

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30 May 2018

language of work or name

English

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publication date

14 January 2013

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30 May 2018

published in

Oncogene

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30 May 2018

volume

32

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30 May 2018

issue

45

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30 May 2018

page(s)

5292-5301

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30 May 2018

https://scigraph.springernature.com/pub.10.1038/onc.2012.571

exact match

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cites work

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

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The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

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The tyrosine phosphatase Shp2 in development and cancer

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The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

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Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms

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Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

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Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

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Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

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SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells

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Cell signaling by receptor tyrosine kinases

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EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

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The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

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Eph-ephrin bidirectional signaling in physiology and disease

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

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How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?

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Negative regulation of EphA2 receptor by Cbl.

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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

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Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.

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Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors

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Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects

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Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

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Endogenous phosphotyrosine signaling in zebrafish embryos.

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A conditional feedback loop regulates Ras activity through EphA2.

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Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

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Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

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Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

21 January 2018

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Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

21 January 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

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SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

21 January 2018

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Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.571

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.571

1 reference

30 May 2018

1 reference

30 May 2018