(Q5446457)

Protein kinase-like domain superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

fibroblast growth factor receptor family

1 reference

Immunoglobulin I-set, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

protein kinase activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

transmembrane receptor protein tyrosine kinase activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

fibroblast growth factor binding

3 references

5 June 2018

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

fibroblast growth factor-activated receptor activity

4 references

7 November 2018

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

7 November 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

2 references

protein tyrosine kinase activity

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1 January 2018

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1-phosphatidylinositol-3-kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

identical protein binding

3 references

8 April 2019

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Structure of FGFR3 Transmembrane Domain Dimer: Implications for Signaling and Human Pathologies

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

transmembrane signaling receptor activity

IPI

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

fibroblast growth factor-activated receptor activity

5 references

8 April 2019

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

fibroblast growth factor binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

protein tyrosine kinase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

3 references

1 reference

8 April 2019

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

integral component of plasma membrane

3 references

8 April 2019

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

Generation of Fgfr3 conditional knockout mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

chondrocyte differentiation

ISS

1 reference

8 April 2019

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

negative regulation of developmental growth

1 reference

8 April 2019

Generation of Fgfr3 conditional knockout mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

endochondral ossification

1 reference

8 April 2019

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

1 reference

8 April 2019

Generation of Fgfr3 conditional knockout mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

fibroblast growth factor receptor apoptotic signaling pathway

ISS

1 reference

8 April 2019

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of phosphatidylinositol 3-kinase activity

positive regulation of phospholipase activity

1 reference

8 April 2019

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

fibroblast growth factor receptor signaling pathway

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

protein phosphorylation

1 reference

8 April 2019

chondrocyte proliferation

1 reference

8 April 2019

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of cell population proliferation

5 references

5 June 2018

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

protein autophosphorylation

1 reference

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

endochondral bone growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of MAPK cascade

1 reference

7 November 2018

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

phosphatidylinositol phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

positive regulation of tyrosine phosphorylation of STAT protein

2 references

8 April 2019

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

skeletal system development

1 reference

8 April 2019

Fibroblast growth factor receptor 3 is a negative regulator of bone growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of cell population proliferation

6 references

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22607&geneProductId=UniProtKB:P22607

positive regulation of ERK1 and ERK2 cascade

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22607

positive regulation of MAPK cascade

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5936

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL502835

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1908391

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1852688

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL377300

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL482968

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545376

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL274654

Gene Atlas image

PBB GE FGFR3 204379 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

tyrosine-protein kinase, active site

1 reference

immunoglobulin subtype 2

1 reference

protein kinase domain

1 reference

immunoglobulin-like domain

1 reference

protein kinase, ATP binding site

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

immunoglobulin I-set

1 reference

immunoglobulin subtype

1 reference

D08.811.913.696.620.682.725.400.179

Identifiers

MeSH descriptor ID

D051498

subject named as

Receptor, Fibroblast Growth Factor, Type 3

0 references

MeSH tree code

0 references

D12.776.543.750.630.442

0 references

D12.776.543.750.750.400.370.875

0 references

D12.776.624.664.700.792

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023