(Q24309328)

English

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

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Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1 (English)

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apoptotic process

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fibroblast growth factor receptor apoptotic signaling pathway

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Gene Ontology release 2020-05-02

Gene Ontology ID

GOA release 2020-03-11

fibroblast growth factor receptor 3

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GOA release 2020-03-11

phosphorylation

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based on heuristic

inferred from title

author name string

Daisuke Harada

1

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Yoshitaka Yamanaka

2

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Koso Ueda

3

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Riko Nishimura

4

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Tsuneo Morishima

5

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Yoshiki Seino

6

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Hiroyuki Tanaka

7

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language of work or name

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publication date

August 2007

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41

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273-81

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2

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Thanatophoric dysplasia: fetal manifestations and prenatal diagnosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

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A new neonatal short limbed dwarfism.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

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Immunohistochemical localization of fibroblast growth factor receptors in the rat mandibular condylar cartilage and tibial cartilage

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

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Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

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Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

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FGF signaling in the developing endochondral skeleton

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

inferred from DOI database lookup

K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 alpha and PLC gamma-independent pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

inferred from DOI database lookup

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

inferred from DOI database lookup

Stat3 as an oncogene

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of Bone Growth by Fibroblast Growth Factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

inferred from DOI database lookup

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

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based on heuristic

inferred from DOI database lookup

Stop codon FGFR3 mutations in thanatophoric dwarfism type 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT1: a modulator of chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-like Growth Factor-1 Rescues the Mutated FGF Receptor 3 (G380R) Expressing ATDC5 Cells From Apoptosis Through Phosphatidylinositol 3-Kinase and MAPK

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation

1 reference

https://api.crossref.org/works/10.1016%2FJ.BONE.2006.11.030

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.BONE.2006.11.030

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