(Q54495902)

30 May 2018

title

Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance. (English)

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30 May 2018

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1

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30 May 2018

Steven A Stacker

series ordinal

2

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30 May 2018

publication date

20 July 2012

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30 May 2018

published in

Growth Factors Journal

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30 May 2018

volume

30

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30 May 2018

issue

5

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30 May 2018

page(s)

283-296

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30 May 2018

Molecular control of lymphatic metastasis.

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Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

21 January 2018

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Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.

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Focus on lymphangiogenesis in tumor metastasis.

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Molecular regulation of angiogenesis and lymphangiogenesis

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Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity

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Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

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Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle

21 January 2018

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Proprotein convertases in health and disease

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Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family.

21 January 2018

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The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man

21 January 2018

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Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis

21 January 2018

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Molecular control of lymphangiogenesis

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Vascular endothelial growth factor D is dispensable for development of the lymphatic system

21 January 2018

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Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

21 January 2018

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Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

21 January 2018

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Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.

21 January 2018

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Vascular endothelial growth factor C induces angiogenesis in vivo.

21 January 2018

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Blocking neuropilin-2 function inhibits tumor cell metastasis

21 January 2018

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VEGF inhibition: insights from preclinical and clinical studies

21 January 2018

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Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

21 January 2018

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Balbiani ring 3 in Chironomus tentans encodes a 185-kDa secretory protein which is synthesized throughout the fourth larval instar

21 January 2018

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A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth

21 January 2018

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Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor-C promotes alloimmunity by amplifying antigen-presenting cell maturation and lymphangiogenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Aspirin intake and survival after breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

An important role of lymphatic vessel activation in limiting acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Proteolytic processing regulates receptor specificity and activity of VEGF-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipop

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Structural determinants of growth factor binding and specificity by VEGF receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Efficacy and safety of sirolimus in lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

A structural superfamily of growth factors containing a cystine knot motif

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Cytologic, immunocytochemical and ultrastructural characterization of lymphangioleiomyomatosis cell clusters in chylous effusions of patients with lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

In fibroblasts Vegf-D expression is induced by cell-cell contact mediated by cadherin-11.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular Endothelial Growth Factor-D Is Increased in Serum of Patients with Lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphangioleiomyomatosis: a disease involving the lymphatic system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphatic vessels in cancer metastasis: bridging the gaps

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

A mutant form of vascular endothelial growth factor (VEGF) that lacks VEGF receptor-2 activation retains the ability to induce vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphangiogenic growth factors as markers of tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Lymphangiogenesis: Molecular mechanisms and future promise

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Novel vascular endothelial growth factor D variants with increased biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Molecular cloning of a novel vascular endothelial growth factor, VEGF-D

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Role of VEGF-C and VEGF-D in lymphangiogenesis in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Inhibition of both the autocrine and the paracrine growth of human leukemia with a fully human antibody directed against vascular endothelial growth factor receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Angiogenic Responses of Vascular Endothelial Growth Factors in Periadventitial Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Vascular endothelial growth factor-D expression in human atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.704917

10.3109/08977194.2012.704917

21 January 2018

Identifiers

DOI

1 reference

30 May 2018

PubMed ID

22817635

1 reference

30 May 2018