(Q54504929)

30 May 2018

title

The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. (English)

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30 May 2018

6

Efthimia K Basdra

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30 May 2018

author name string

Panos G Ziros

1

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30 May 2018

Andrea-Paola Rojas Gil

2

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30 May 2018

Tassos Georgakopoulos

3

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30 May 2018

Ioannis Habeos

4

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30 May 2018

Dimitris Kletsas

5

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Athanasios G Papavassiliou

7

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30 May 2018

language of work or name

English

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publication date

17 April 2002

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30 May 2018

Journal of Biological Chemistry

published in

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30 May 2018

volume

277

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30 May 2018

issue

26

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30 May 2018

page(s)

23934-23941

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30 May 2018

Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling

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Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

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Cbfa1 isoforms exert functional differences in osteoblast differentiation

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Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

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Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2.

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Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation

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Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells

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Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells

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Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins.

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Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis

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Cells with osteoblastic phenotypes can be explanted from human gingiva and periodontal ligament

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MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

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Mechanical stress induces DNA synthesis in PDL fibroblasts by a mechanism unrelated to autocrine growth factor action

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor

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Cbfa1: a molecular switch in osteoblast biology

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Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation.

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A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element

21 January 2018

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin

21 January 2018

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Role of Cbfa1 in osteoblast differentiation and function

21 January 2018

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The osteoblast: a sophisticated fibroblast under central surveillance

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Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

21 January 2018

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

21 January 2018

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Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells

21 January 2018

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Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor

21 January 2018

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AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element

21 January 2018

1 reference

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Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues

21 January 2018

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Low mechanical signals strengthen long bones

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M109881200

1 reference

30 May 2018

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30 May 2018