(Q54509885)

30 May 2018

title

Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome. (English)

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author name string

Kirill B Gromadski

series ordinal

1

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publication date

7 March 2004

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Nature Structural & Molecular Biology

published in

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volume

11

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issue

4

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page(s)

316-322

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Fidelity of aminoacyl-tRNA selection on the ribosome: kinetic and structural mechanisms

cites work

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

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Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome

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Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

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Insights into the decoding mechanism from recent ribosome structures

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Dissociation rate of cognate peptidyl-tRNA from the A-site of hyper-accurate and error-prone ribosomes

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Streptomycin preferentially perturbs ribosomal proofreading

31 March 2020

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Kinetic determinants of high-fidelity tRNA discrimination on the ribosome

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Initial binding of the elongation factor Tu.GTP.aminoacyl-tRNA complex preceding codon recognition on the ribosome.

31 March 2020

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Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome

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Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome

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Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.

31 March 2020

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Paromomycin and dihydrostreptomycin binding to Escherichia coli ribosomes

31 March 2020

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Mutations in 23 S ribosomal RNA perturb transfer RNA selection and can lead to streptomycin dependence.

31 March 2020

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Comparison of the misreading induced by streptomycin and neomycin

31 March 2020

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The Binding of Non-cognate Tyr-tRNATyr to Poly(uridylic acid)-Programmed Escherichia coli Ribosomes

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Proofreading of the codon-anticodon interaction on ribosomes

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Functional studies of the 900 tetraloop capping helix 27 of 16S ribosomal RNA.

31 March 2020

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Decoding fidelity at the ribosomal A and P sites: influence of mutations in three different regions of the decoding domain in 16S rRNA.

31 March 2020

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Probing ribosome structure and function by mutagenesis

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Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus

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A functional interaction between ribosomal proteins S7 and S11 within the bacterial ribosome

31 March 2020

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X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli

31 March 2020

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Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process

31 March 2020

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Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

31 March 2020

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A twisted tRNA intermediate sets the threshold for decoding

31 March 2020

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Transient conformational states of aminoacyl-tRNA during ribosome binding catalyzed by elongation factor Tu.

31 March 2020

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Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

31 March 2020

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Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox

31 March 2020

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GTPase activation of elongation factors Tu and G on the ribosome

31 March 2020

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The guanine nucleotide-binding switch in three dimensions

31 March 2020

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Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu.

31 March 2020

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Selection of the mRNA translation initiation region by Escherichia coli ribosomes

31 March 2020

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GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs

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Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.

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Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

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Identifiers

DOI

10.1038/NSMB742

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30 May 2018

Dimensions Publication ID

1014670925

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30 May 2018