(Q54520619)

30 May 2018

title

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions. (English)

1 reference

30 May 2018

author

Jun Shirakawa

5

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30 May 2018

author name string

A Nakamura

1

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30 May 2018

Y Togashi

2

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30 May 2018

K Orime

3

1 reference

30 May 2018

K Sato

4

1 reference

30 May 2018

M Ohsugi

6

1 reference

30 May 2018

N Kubota

7

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30 May 2018

T Kadowaki

8

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30 May 2018

Y Terauchi

9

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30 May 2018

publication date

29 March 2012

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30 May 2018

published in

Diabetologia

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30 May 2018

volume

55

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30 May 2018

issue

6

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30 May 2018

page(s)

1745-1754

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30 May 2018

https://scigraph.springernature.com/pub.10.1007/s00125-012-2521-5

exact match

0 references

cites work

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Allosteric activators of glucokinase: potential role in diabetes therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Effect of long-term treatment with a small-molecule glucokinase activator on glucose metabolism, lipid profiles and hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Assessing the potential of glucokinase activators in diabetes therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

A dominant role for glucose in beta cell compensation of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

ATP-sensitive potassium channelopathies: focus on insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Control of pancreatic β cell regeneration by glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Pdx1 restores beta cell function in Irs2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2521-5

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22456697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22456697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00125-012-2521-5

1 reference

30 May 2018

PubMed ID

22456697

1 reference

30 May 2018