(Q54528928)

31 May 2018

title

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. (English)

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31 May 2018

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2

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31 May 2018

author name string

Kazuhiro Maeda

1

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31 May 2018

Nobuyuki Udagawa

3

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31 May 2018

Shunsuke Uehara

4

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31 May 2018

Akihiro Ishihara

5

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31 May 2018

Toshihide Mizoguchi

6

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31 May 2018

Yuichiro Kikuchi

7

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31 May 2018

Ichiro Takada

8

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31 May 2018

Shigeaki Kato

9

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31 May 2018

Shuichi Kani

10

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31 May 2018

Michiru Nishita

11

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31 May 2018

Keishi Marumo

12

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31 May 2018

T John Martin

13

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31 May 2018

Yasuhiro Minami

14

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31 May 2018

Naoyuki Takahashi

15

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31 May 2018

language of work or name

English

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publication date

19 February 2012

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31 May 2018

published in

Nature Medicine

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31 May 2018

volume

18

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31 May 2018

issue

3

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31 May 2018

page(s)

405-412

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31 May 2018

https://scigraph.springernature.com/pub.10.1038/nm.2653

exact match

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cites work

Genetic regulation of osteoclast development and function

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Osteoblastic cells are involved in osteoclast formation.

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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Osteoclast differentiation and activation

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Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

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Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways

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Identification of cell cycle-arrested quiescent osteoclast precursors in vivo

21 January 2018

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Linking colorectal cancer to Wnt signaling

21 January 2018

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21 January 2018

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21 January 2018

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

21 January 2018

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21 January 2018

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

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Lrp5 functions in bone to regulate bone mass

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

21 January 2018

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The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

21 January 2018

1 reference

The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells

21 January 2018

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The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation

21 January 2018

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Pathogenesis of bone erosions in rheumatoid arthritis

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

21 January 2018

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Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling

21 January 2018

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Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development

21 January 2018

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Wnt signaling regulates hemopoiesis through stromal cells.

21 January 2018

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Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts

21 January 2018

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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

21 January 2018

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The hematopoietic transcription factor PU.1 regulates RANK gene expression in myeloid progenitors

21 January 2018

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c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

21 January 2018

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Induction of cPLA2 in lung epithelial cells and non-small cell lung cancer is mediated by Sp1 and c-Jun

21 January 2018

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Expression and function of wingless and frizzled homologs in rheumatoid arthritis.

21 January 2018

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A novel member of the leukocyte receptor complex regulates osteoclast differentiation

21 January 2018

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

21 January 2018

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

21 January 2018

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Matrix-embedded cells control osteoclast formation

21 January 2018

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Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors

21 January 2018

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The role of Wnt proteins in arthritis

21 January 2018

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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

21 January 2018

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Wnt5a regulates distinct signalling pathways by binding to Frizzled2

21 January 2018

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Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2.

21 January 2018

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Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome

21 January 2018

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Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases

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Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.

21 January 2018

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Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

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Autoimmunity to type II collagen an experimental model of arthritis

21 January 2018

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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis

21 January 2018

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A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

21 January 2018

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A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo

21 January 2018

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12 December 2020

RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis

1 reference

12 December 2020

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation

1 reference

12 December 2020

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue

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12 December 2020

Dickkopf-1 is a master regulator of joint remodeling

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12 December 2020

Tumor necrosis factor-alpha promotes the expression of osteoprotegerin in rheumatoid synovial fibroblasts

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12 December 2020

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.2653

1 reference

31 May 2018

PubMed ID

22344299

1 reference

31 May 2018