(Q54560146)

31 May 2018

title

The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. (English)

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31 May 2018

main subject

spinal muscular atrophy

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1 reference

4

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31 May 2018

Paul Lingor

15

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31 May 2018

Peter Claus

20

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31 May 2018

Andre Zeug

object named as

Andre Zeug

2

0 references

Evgeni G Ponimaskin

object named as

Evgeni Ponimaskin

17

0 references

author name string

Anna Nölle

1

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31 May 2018

Jeroen van Bergeijk

3

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31 May 2018

Ralf Gerhard

5

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31 May 2018

Hella Brinkmann

6

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31 May 2018

Sarah Al Rayes

7

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31 May 2018

Niko Hensel

8

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31 May 2018

Yvonne Schill

9

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31 May 2018

David Apkhazava

10

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31 May 2018

Sibylle Jablonka

11

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31 May 2018

Jana O'mer

12

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31 May 2018

Ratnesh Kumar Srivastav

13

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31 May 2018

Anne Baasner

14

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31 May 2018

Brunhilde Wirth

16

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31 May 2018

Rainer Niedenthal

18

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31 May 2018

Claudia Grothe

19

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31 May 2018

publication date

14 September 2011

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31 May 2018

published in

Human Molecular Genetics

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31 May 2018

volume

20

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31 May 2018

issue

24

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31 May 2018

page(s)

4865-4878

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31 May 2018

The neurobiology of childhood spinal muscular atrophy.

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

21 January 2018

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Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

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Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications

21 January 2018

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Spinal muscular atrophies reveal motor neuron vulnerability to defects in ribonucleoprotein handling

21 January 2018

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A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

21 January 2018

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Macromolecular complexes: SMN--the master assembler

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy

21 January 2018

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Survival motor neuron (SMN) protein: role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and development.

21 January 2018

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Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons

21 January 2018

1 reference

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Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

21 January 2018

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Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?

21 January 2018

1 reference

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Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy

21 January 2018

1 reference

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Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice

21 January 2018

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Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

21 January 2018

1 reference

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The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus.

21 January 2018

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Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis.

21 January 2018

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Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model.

21 January 2018

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Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis

21 January 2018

1 reference

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RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability

21 January 2018

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Rho family GTPases as key regulators for neuronal network formation.

21 January 2018

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SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells.

21 January 2018

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Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Analysis of FRET signals in the presence of free donors and acceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

A mouse model for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Signal-regulated ADF/cofilin activity and growth cone motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Myosin light chain phosphorylation and growth cone motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Regulation of growth cone actin dynamics by ADF/cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Actin has a molecular scaffolding, not propulsive, role in presynaptic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Fibroblast growth factor-2 regulates the stability of nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR425

21 January 2018

Identifiers

DOI

10.1093/HMG/DDR425

1 reference

31 May 2018

PubMed ID

21920940

1 reference

31 May 2018