(Q54564848)

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Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

6

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Zixin Deng

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

author name string

Mi-Jin Lee

1

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Dekun Kong

2

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Kyuboem Han

3

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

David H Sherman

4

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Linquan Bai

5

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Shuangjun Lin

7

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Eung-Soo Kim

8

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PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

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publication date

1 March 2012

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

Applied Microbiology and Biotechnology

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

95

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

1

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

157-168

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

https://scigraph.springernature.com/pub.10.1007/s00253-012-3955-x

0 references

To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations

1 reference

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The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

1 reference

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21 January 2018

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

1 reference

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21 January 2018

Polyene antibiotic biosynthesis gene clusters.

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Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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How do the polyene macrolide antibiotics affect the cellular membrane properties?

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Probing the structure-function relationship of polyene macrolides: engineered biosynthesis of soluble nystatin analogues.

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21 January 2018

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

1 reference

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21 January 2018

Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.

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21 January 2018

Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei

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Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.

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21 January 2018

Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus

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21 January 2018

Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

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The candicidin gene cluster from Streptomyces griseus IMRU 3570.

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Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups

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Cholesterol and ergosterol influence nystatin surface aggregation: relation to pore formation

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Invasive fungal infections: a review of epidemiology and management options

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Antifungal antibiotics

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21 January 2018

Remarkable structural similarities between diverse glycosyltransferases

1 reference

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21 January 2018

Analysis and functional expression of NPP pathway-specific regulatory genes in Pseudonocardia autotrophica

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21 January 2018

Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica

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Synthesis and macrophage activation of lentinan-mimic branched amino polysaccharides: curdlans having N-Acetyl-d-glucosamine branches

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Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

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21 January 2018

Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.

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21 January 2018

Current status and future of antifungal therapy for systemic mycoses

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Two polyene amides produced by genetically modified Streptomyces diastaticus var. 108.

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21 January 2018

Invasive candidiasis in immunocompromised hospitalized patients.

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21 January 2018

Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.

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21 January 2018

Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.

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21 January 2018

Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity

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Antibiotic glycosyltransferases

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Glycodiversification for the optimization of the kanamycin class aminoglycosides

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Polyene macrolide antibiotics and their applications in human therapy

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Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455.

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21 January 2018

Identifiers

10.1007/S00253-012-3955-X

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/22382166

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