(Q54566344)

1 June 2018

title

Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. (English)

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1 June 2018

main subject

pulmonary hypertension

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Mirjana Jerkic

1

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1 June 2018

Mohammed G Kabir

2

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1 June 2018

Adrienne Davies

3

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1 June 2018

Lisa X Yu

4

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1 June 2018

Brendan A S McIntyre

5

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1 June 2018

Nasir W Husain

6

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1 June 2018

Masahiro Enomoto

7

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1 June 2018

Valentin Sotov

8

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1 June 2018

Mansoor Husain

9

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1 June 2018

Mark Henkelman

10

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1 June 2018

Jaques Belik

11

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1 June 2018

Michelle Letarte

12

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1 June 2018

publication date

22 August 2011

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1 June 2018

published in

Cardiovascular Research

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1 June 2018

volume

92

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1 June 2018

issue

3

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1 June 2018

page(s)

375-384

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1 June 2018

The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2

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Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative

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Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

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Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

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Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.

21 January 2018

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Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

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Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

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Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.

21 January 2018

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Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

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A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia

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Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia

21 January 2018

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Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

21 January 2018

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Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice

21 January 2018

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Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells.

21 January 2018

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Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme

21 January 2018

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Contribution of oxidative stress to pulmonary arterial hypertension

21 January 2018

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Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization

21 January 2018

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Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations

21 January 2018

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Reactive oxygen species and vascular remodelling in hypertension: still alive

21 January 2018

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Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production

21 January 2018

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Chemistry and antihypertensive effects of tempol and other nitroxides

21 January 2018

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Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial meta-analyses

21 January 2018

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BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.

21 January 2018

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Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

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Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice

21 January 2018

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Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

21 January 2018

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Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CVR/CVR232

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1 June 2018

PubMed ID

21859819

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1 June 2018