(Q54595296)

1 June 2018

title

Functional analysis of conserved histidine residues in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis. (English)

1 reference

1 June 2018

Cephalosporium acremonium

main subject

object named as

Cephalosporium acremonium

1 reference

Tan DS

1

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1 June 2018

Sim TS

series ordinal

2

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1 June 2018

language of work or name

English

0 references

publication date

1 January 1996

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1 June 2018

Journal of Biological Chemistry

published in

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1 June 2018

volume

271

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1 June 2018

page(s)

889-894

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1 June 2018

issue

2

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1 June 2018

describes a project that uses

site-directed mutagenesis

1 reference

based on heuristic

inferred from title

cites work

The biosynthesis of penicillins and cephalosporins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

X-ray absorption spectroscopic studies of the high-spin iron(II) active site of isopenicillin N synthase: evidence for Fe-S interaction in the enzyme-substrate complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cloning and comparative sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

DNA sequencing with chain-terminating inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

NMR studies of the active site of isopenicillin N synthase, a non-heme iron(II) enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Analysis of the role of cysteine residues in isopenicillin N synthetase activity by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Modification of vertebrate and algal prolyl 4-hydroxylases and vertebrate lysyl hydroxylase by diethyl pyrocarbonate. Evidence for histidine residues in the catalytic site of 2-oxoglutarate-coupled dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Molecular characterization of flavanone 3 beta-hydroxylases. Consensus sequence, comparison with related enzymes and the role of conserved histidine residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Site-directed mutagenesis of the alpha subunit of human prolyl 4-hydroxylase. Identification of three histidine residues critical for catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

Electron spin echo envelope modulation studies of the copper(II)-substituted derivative of isopenicillin N synthase: a structural and spectroscopic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.2.889

21 January 2018

Identifiers

DOI

10.1074/JBC.271.2.889

1 reference

1 June 2018

PubMed ID

8557701

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1 June 2018