(Q54631073)

1 June 2018

title

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. (English)

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14

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María Lourdes Arbonés

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Stefanos Leptidis

object named as

Stefanos Leptidis

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author name string

Paula A da Costa Martins

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Kanita Salic

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Monika M Gladka

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Anne-Sophie Armand

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Hamid el Azzouzi

6

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Arne Hansen

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Christina J Coenen-de Roo

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Marti F Bierhuizen

9

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Roel van der Nagel

10

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Joyce van Kuik

11

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Roel de Weger

12

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Alain de Bruin

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Thomas Eschenhagen

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Leon J De Windt

17

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1 June 2018

publication date

21 November 2010

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1 June 2018

published in

Nature Cell Biology

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1 June 2018

volume

12

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page(s)

1220-1227

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issue

12

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https://scigraph.springernature.com/pub.10.1038/ncb2126

exact match

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cites work

MicroRNAs: genomics, biogenesis, mechanism, and function

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MicroRNAs: a developing story

21 January 2018

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MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice

21 January 2018

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Control of stress-dependent cardiac growth and gene expression by a microRNA

21 January 2018

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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

21 January 2018

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

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MicroRNA-133 controls cardiac hypertrophy

21 January 2018

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microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

21 January 2018

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MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts

21 January 2018

1 reference

Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling

21 January 2018

1 reference

MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure

21 January 2018

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Sizing up the heart: development redux in disease.

21 January 2018

1 reference

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

1 reference

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

21 January 2018

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Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

21 January 2018

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Transcriptional regulation by calcium, calcineurin, and NFAT

21 January 2018

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Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

21 January 2018

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Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy

21 January 2018

1 reference

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

21 January 2018

1 reference

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

21 January 2018

1 reference

NFAT signaling: choreographing the social lives of cells

21 January 2018

1 reference

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

21 January 2018

1 reference

Specificity, duplex degradation and subcellular localization of antagomirs

21 January 2018

1 reference

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy

21 January 2018

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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

21 January 2018

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Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation

21 January 2018

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Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo

21 January 2018

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NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure

21 January 2018

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12 December 2020

MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction

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12 December 2020

Mixed signals in heart failure: cancer rules

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12 December 2020

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

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12 December 2020

Identifiers

DOI

10.1038/NCB2126

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1 June 2018

PubMed ID

21102440

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1 June 2018