(Q54671652)

2 June 2018

title

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. (English)

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2 June 2018

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7

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2 June 2018

Vito Fanelli

8

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2 June 2018

Virgínia S. Lemos

12

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2 June 2018

Fernando Queiroz Cunha

15

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2 June 2018

Emilio Hirsch

18

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2 June 2018

Erica L Martin

Erica L Martin

1

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Arthur S Slutsky

16

Arthur S Slutsky

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2 June 2018

Mauro M Teixeira

19

Mauro M Teixeira

1 reference

2 June 2018

Valeria Puntorieri

6

Valeria Puntorieri

1 reference

2 June 2018

Barbara Assenzio

5

Barbara Assenzio

1 reference

2 June 2018

Martino Bosco

9

Martino Bosco

1 reference

2 June 2018

Luisa Delsedime

10

Luisa Delsedime

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2 June 2018

Marco Ranieri

20

V Marco Ranieri

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2 June 2018

author name string

Danielle G Souza

2

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2 June 2018

Caio T Fagundes

3

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2 June 2018

Flavio A Amaral

4

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2 June 2018

Jose F Pinho

11

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2 June 2018

Fabricio O Souto

13

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2 June 2018

Jose C Alves-Filho

14

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2 June 2018

Thomas Ruckle

17

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2 June 2018

language of work or name

English

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publication date

27 May 2010

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2 June 2018

American Journal of Respiratory and Critical Care Medicine

published in

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2 June 2018

volume

182

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2 June 2018

page(s)

762-773

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2 June 2018

issue

6

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2 June 2018

Mechanisms of sepsis-induced organ dysfunction

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1 reference

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Inferences, questions and possibilities in Toll-like receptor signalling

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Counteracting clotting in sepsis

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Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

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Hydrocortisone therapy for patients with septic shock

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Interleukin 18 in the heart

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Down-regulation of CXCR2 on Neutrophils in Severe Sepsis Is Mediated by Inducible Nitric Oxide Synthase–derived Nitric Oxide

21 January 2018

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Failure of neutrophil chemotactic function in septic patients.

21 January 2018

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Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.

21 January 2018

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

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Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice

21 January 2018

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PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

21 January 2018

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Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury.

21 January 2018

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Cellular signaling mechanisms in alcohol-induced liver damage

21 January 2018

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Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease

21 January 2018

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21 January 2018

PI3K class IB pathway

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

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Role of phosphatidylinositol 3-kinase-gamma in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis.

21 January 2018

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Lipoproteins in inflammation and sepsis. II. Clinical aspects.

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Phosphoinositide-3 kinase gamma kinase activity significantly contributes to the pathophysiology of sepsis and multiorgan failure

21 January 2018

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

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Sepsis: current concepts in intracellular signaling

21 January 2018

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

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Leading-edge research: PtdIns(3,4,5)P3 and directed migration.

21 January 2018

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Death to sepsis: targeting apoptosis pathways in sepsis

21 January 2018

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PI 3-kinase, Akt and cell survival

21 January 2018

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Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection

21 January 2018

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Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space

21 January 2018

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Cellular mechanisms in sepsis

21 January 2018

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New players in TLR-mediated innate immunity: PI3K and small Rho GTPases.

21 January 2018

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Neutrophils in the pathogenesis of sepsis

21 January 2018

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Neutrophils in development of multiple organ failure in sepsis

21 January 2018

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Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis.

21 January 2018

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Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

21 January 2018

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The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling

21 January 2018

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GRKs and arrestins: regulators of migration and inflammation

21 January 2018

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Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201001-0088OC

Leukocyte PI3K and PI3K have temporally distinct roles for leukocyte recruitment in vivo

21 January 2018

1 reference

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An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

21 January 2018

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PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

21 January 2018

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Twice upon a time: PI3K's secret double life exposed

21 January 2018

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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

21 January 2018

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Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

21 January 2018

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10.1164/RCCM.201001-0088OC

21 January 2018

Identifiers

DOI

1 reference

2 June 2018

PubMed ID

20508212

1 reference

2 June 2018