(Q55039005)

16 June 2018

title

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. (English)

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16 June 2018

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Goodwell Nzou

1

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16 June 2018

R T Wicks

2

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16 June 2018

E E Wicks

3

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16 June 2018

S A Seale

4

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16 June 2018

C H Sane

5

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16 June 2018

A Chen

6

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16 June 2018

S V Murphy

7

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16 June 2018

J D Jackson

8

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16 June 2018

A J Atala

9

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16 June 2018

language of work or name

English

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publication date

9 May 2018

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16 June 2018

published in

Scientific Reports

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16 June 2018

volume

8

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16 June 2018

issue

1

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16 June 2018

page(s)

7413

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16 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

9 May 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5943588/fullTextXML

inferred from PubMed Central ID database lookup

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Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells.

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Platelet-derived Growth Factor Receptor-beta is Differentially Regulated in Primary Mouse Pericytes and Brain Slices

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells

16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Vitamin C. Biosynthesis, recycling and degradation in mammals

16 June 2018

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Astrocytes promote myelination in response to electrical impulses

16 June 2018

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16 June 2018

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MPP+ Analogs Acting on Mitochondria and Inducing Neuro-Degeneration

16 June 2018

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Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation

16 June 2018

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Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

16 June 2018

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Inflammatory mediators and modulation of blood-brain barrier permeability

16 June 2018

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High altitude cerebral edema and acute mountain sickness. A pathophysiology update

16 June 2018

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16 June 2018

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16 June 2018

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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

16 June 2018

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16 June 2018

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16 June 2018

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

16 June 2018

1 reference

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Fine structural localization of a blood-brain barrier to exogenous peroxidase

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

The blood-brain barrier to proteins under normal and pathological conditions

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: dependence on sodium but not calcium io

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Effect of histamine and antagonists on electrical resistance across the blood-brain barrier in rat brain-surface microvessels

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Glial cells and neurons induce blood-brain barrier related enzymes in cultured cerebral endothelial cells.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood-Brain Barrier.

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

13 August 2018

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Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Microglia of medicinal leech (Hirudo medicinalis) express a specific activation marker homologous to vertebrate ionized calcium-binding adapter molecule 1 (Iba1/alias aif-1).

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Multicellular self-assembled spheroidal model of the blood brain barrier

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

Glial cells influence polarity of the blood-brain barrier.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

A mechanism underlying the lack of a blood-brain barrier to peroxidase in virally induced brain tumors

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943588

2015 Alzheimer's disease facts and figures

13 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-018-25603-5

7 January 2021

Pericytes and the blood–brain barrier: recent advances and implications for the delivery of CNS therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41598-018-25603-5

7 January 2021

Neutral Amino Acid Transport Properties of Cerebral Endothelial Cells in Vitro

1 reference

https://api.crossref.org/works/10.1038%2FS41598-018-25603-5

7 January 2021

Wnt signaling in the vasculature

1 reference

https://api.crossref.org/works/10.1038%2FS41598-018-25603-5

7 January 2021

Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP

1 reference

https://api.crossref.org/works/10.1038%2FS41598-018-25603-5

7 January 2021

10.1038/S41598-018-25603-5

Identifiers

DOI

1 reference

16 June 2018

PMCID

5943588

1 reference

16 June 2018

PubMed ID

29743549

1 reference

16 June 2018