(Q55041190)

16 June 2018

title

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. (English)

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16 June 2018

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4

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16 June 2018

author name string

Purificación Muñoz

series ordinal

1

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16 June 2018

Raquel Blanco

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2

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16 June 2018

Juana M Flores

series ordinal

3

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16 June 2018

language of work or name

English

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publication date

4 September 2005

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16 June 2018

published in

Nature Genetics

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16 June 2018

volume

37

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16 June 2018

page(s)

1063-1071

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16 June 2018

issue

10

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16 June 2018

https://scigraph.springernature.com/pub.10.1038/ng1633

exact match

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cites work

Protection of mammalian telomeres

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7 January 2021

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

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7 January 2021

Homologous recombination generates T-loop-sized deletions at human telomeres

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7 January 2021

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

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7 January 2021

Many ways to telomere dysfunction: in vivo studies using mouse models

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7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

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7 January 2021

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

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7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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7 January 2021

Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

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7 January 2021

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

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7 January 2021

Control of human telomere length by TRF1 and TRF2

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7 January 2021

Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

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7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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7 January 2021

Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

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7 January 2021

Nucleotide excision repair and human syndromes

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7 January 2021

Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription

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7 January 2021

Molecular mechanism of nucleotide excision repair.

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7 January 2021

Nucleotide excision repair: from E. coli to man.

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7 January 2021

DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts

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7 January 2021

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

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7 January 2021

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

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7 January 2021

Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF

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7 January 2021

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

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7 January 2021

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

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7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

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7 January 2021

DNA damage foci at dysfunctional telomeres

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7 January 2021

DNA repair: spot(light)s on chromatin.

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7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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7 January 2021

Deletion of Ku86 causes early onset of senescence in mice

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7 January 2021

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

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7 January 2021

Dyskeratosis congenita and telomerase

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7 January 2021

Identifiers

DOI

10.1038/NG1633

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16 June 2018

Dimensions Publication ID

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16 June 2018