(Q55065627)

English

Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort.

scientific article published in January 2016

In more languages

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scholarly article

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort. (English)

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

author name string

Howard A Burris

1

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Suzanne Bakewell

2

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Johanna C Bendell

3

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Jeffrey Infante

4

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Suzanne F Jones

5

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

David R Spigel

6

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Glen J Weiss

7

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Ramesh K Ramanathan

8

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Angela Ogden

9

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Daniel Von Hoff

10

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

publication date

1 January 2016

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

1

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

6

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

e000154

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Ruthenium Complexes: An Emerging Ground to the Development of Metallopharmaceuticals for Cancer Therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

A ruthenium(II) β-carboline complex induced p53-mediated apoptosis in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Tumor stress inside out: cell-extrinsic effects of the unfolded protein response in tumor cells modulate the immunological landscape of the tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Molecular mechanisms of cisplatin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

The critical role of GRP78 in physiologic and pathologic stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Stress induction of GRP78/BiP and its role in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Gallium and other main group metal compounds as antitumor agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Recent developments in the field of tumor-inhibiting metal complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Cisplatin resistance and oncogenes--a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

18 June 2018

Anticancer cationic ruthenium nanovectors: from rational molecular design to cellular uptake and bioactivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

Overexpression of glucose-regulated protein 78 in colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

13 August 2018

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5548977

30 November 2018

Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/28848672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/ESMOOPEN-2016-000154

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

1 reference

Europe PubMed Central

16 June 2018

http://europepmc.org/abstract/PMC/5548977

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