(Q5519727)

canonical SMILES

CC(=CCCC1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=CC5CC6C4(O3)C(C5=O)(OC6(C)C)CC=C(C)C(=O)O)CC=C(C)C)C)C

1 reference

Gambogic acid (English)

14 February 2019

CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C

1 reference

Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Gambogic acid (English)

14 February 2019

10 references

Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi

Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi

Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells

Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Isogambogic acid and isomorellinol fromGarcinia hanburyi

Cytotoxic xanthones from Garcinia hanburyi

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway

Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells

Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1.

Identifiers

InChI

InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1

1 reference

Gambogic acid (English)

14 February 2019

2 references

imported from Wikimedia project

Gambogic acid (English)

14 February 2019

ChEBI release 2020-09-01

CAS Registry Number

2752-65-0

2 references

English Wikipedia

https://commonchemistry.cas.org/detail?cas_rn=2752-65-0

9 April 2021

ChemSpider ID

8027898

1 reference

imported from Wikimedia project

2 references

Gambogic acid (English)

retrieved

14 February 2019

PubChem CID

9852185

ChEBI ID

67521

mapping relation type

exact match

2 references

ChEBI release 2019-10-02

International Chemical Identifier

InChI

InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1

ChEMBL ID

CHEMBL555017

1 reference

imported from Wikimedia project

1 reference

1 reference

EC number

631-063-8

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.159.336

retrieved

27 December 2018

ECHA Substance Infocard ID

Gambogic acid (English)

quotation

CAS no.: 2752-65-0 (English)

100.159.336

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.159.336

retrieved

27 December 2018

Gambogic acid (English)

quotation

CAS no.: 2752-65-0 (English)

UNII

8N585K83U2

1 reference