(Q55216568)

English

Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5

scientific article published on 30 December 2009

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scholarly article

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26 June 2018

Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling (English)

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26 June 2018

cellular response to insulin-like growth factor stimulus

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Gene Ontology release 2020-05-02

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4

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26 June 2018

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Andrew Sunters

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26 June 2018

Victoria J Armstrong

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26 June 2018

Gul Zaman

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26 June 2018

Yoshiaki Kawano

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Lance E Lanyon

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26 June 2018

Joanna S Price

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26 June 2018

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30 December 2009

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26 June 2018

Journal of Biological Chemistry

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26 June 2018

285

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26 June 2018

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26 June 2018

8743-8758

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26 June 2018

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Beta-catenin levels influence rapid mechanical responses in osteoblasts

1 reference

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1 reference

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30 June 2018

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

1 reference

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30 June 2018

Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling

1 reference

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1 reference

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30 June 2018

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

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30 June 2018

Akt1 in osteoblasts and osteoclasts controls bone remodeling

1 reference

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30 June 2018

AKT/PKB signaling: navigating downstream

1 reference

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30 June 2018

Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha

1 reference

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1 reference

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Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes.

1 reference

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1 reference

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30 June 2018

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

1 reference

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30 June 2018

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1 reference

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30 June 2018

Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action

1 reference

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30 June 2018

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

1 reference

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30 June 2018

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

1 reference

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30 June 2018

Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2.

1 reference

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Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells

1 reference

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30 June 2018

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30 June 2018

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling

1 reference

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30 June 2018

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

1 reference

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30 June 2018

Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response

1 reference

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Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass

1 reference

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30 June 2018

Fluid shear stress induces beta-catenin signaling in osteoblasts.

1 reference

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Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells

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Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

Mechanotransduction in stretched osteocytes--temporal expression of immediate early and other genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838297

13 August 2018

Linkage of Rapid Estrogen Action to MAPK Activation by ER -Shc Association and Shc Pathway Activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.027086

21 January 2018

Bone adaptation requires oestrogen receptor-α

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.027086

21 January 2018

Effect of strain on bone nodule formation by rat osteogenic cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptors and human bone cells: immunocytochemical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of osteocytes to biomechanical stress in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 increases the skeletal response to mechanical loading

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of prostaglandins and nitric oxide in the response of bone to mechanical forces

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and IGF-I activate the Akt pathway in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20042609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.027086

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20042609%20AND%20SRC:MED&resulttype=core&format=json

26 June 2018

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20042609%20AND%20SRC:MED&resulttype=core&format=json

26 June 2018

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20042609%20AND%20SRC:MED&resulttype=core&format=json

26 June 2018

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