(Q55230759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

title

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

0 references

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

author name string

Li-Hui Bao

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Ya-Nan Zhang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Jian-Nan Zhang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Li Gu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Hui-Min Yang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Yi-Ying Huang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Ning Xia

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

publication date

2 May 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neuroinflammation

25 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

page(s)

131

1 reference

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25 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

25 March 2020

copyright license

start time

2 May 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5932803/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/s12974-018-1175-8

0 references

cites work

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

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Neurotoxic reactive astrocytes are induced by activated microglia

30 June 2018

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Urate as a Marker of Risk and Progression of Neurodegenerative Disease

30 June 2018

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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

30 June 2018

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Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

30 June 2018

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Gamma-decanolactone inhibits iNOS and TNF-alpha production by lipopolysaccharide-activated microglia in N9 cells

30 June 2018

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Toll-Like Receptor 4 Deficiency Impairs Motor Coordination

30 June 2018

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Prospective study of plasma urate and risk of Parkinson disease in men and women

30 June 2018

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Neuroinflammation in Parkinson's disease and its potential as therapeutic target

30 June 2018

1 reference

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Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release

30 June 2018

1 reference

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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

30 June 2018

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Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial

30 June 2018

1 reference

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Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury

30 June 2018

1 reference

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Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders

30 June 2018

1 reference

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Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration

30 June 2018

1 reference

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Protection of dopaminergic cells by urate requires its accumulation in astrocytes

30 June 2018

1 reference

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Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons

30 June 2018

1 reference

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Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Urate as a marker of development and progression in Parkinson's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Caffeine and uric acid mediate glutathione synthesis for neuroprotection

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Microglial activation and chronic neurodegeneration

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy

30 June 2018

1 reference

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The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

30 June 2018

1 reference

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Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease

30 June 2018

1 reference

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Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures

30 June 2018

1 reference

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30 June 2018

1 reference

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Serum urate as a predictor of clinical and radiographic progression in Parkinson disease

30 June 2018

1 reference

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Plasma urate and risk of Parkinson's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Free radical scavenging, DNA protection, and inhibition of lipid peroxidation mediated by uric acid

30 June 2018

1 reference

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Uric acid protects against secondary damage after spinal cord injury

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons.

30 June 2018

1 reference

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Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion

30 June 2018

1 reference

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Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

30 June 2018

1 reference

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Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

30 June 2018

1 reference

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Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease.

30 June 2018

1 reference

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Cytokines in Parkinson's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Rate of cell death in parkinsonism indicates active neuropathological process

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

One year safety and efficacy of inosine to increase the serum urate level for patients with Parkinson's disease in Japan.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Dyrk2 mediated the release of proinflammatory cytokines in LPS-induced BV2 cells.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Microglia emerge as central players in brain disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

An environment-dependent transcriptional network specifies human microglia identity

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Serum uric acid levels and freezing of gait in Parkinson's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3β signaling pathway.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Further characterisation of the LPS model of Parkinson's disease: a comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Quantification of Total Oxidant Scavenging Capacity of Antioxidants for Peroxynitrite, Peroxyl Radicals, and Hydroxyl Radicals

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5932803

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

30 November 2018

1 reference

12 December 2020

Effect of uric acid on liver injury during hemorrhagic shock

1 reference

12 December 2020

The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS

1 reference

12 December 2020

Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity

1 reference

12 December 2020

Uric acid and neuroprotection

1 reference

12 December 2020

10.1186/S12974-018-1175-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 March 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12974-018-1175-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720230%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference