(Q55476334)

English

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

scientific article published in December 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

angiogenesis inhibitor

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Feldkamp MM

1

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

Lau N

2

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

Guha A

3

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

language of work or name

0 references

publication date

1 December 1999

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

18

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

52

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

7514-7526

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203105

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203105

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

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21 January 2018

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

1 reference

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21 January 2018

Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins

1 reference

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21 January 2018

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

1 reference

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21 January 2018

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

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21 January 2018

Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras.

1 reference

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21 January 2018

Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor

1 reference

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21 January 2018

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

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21 January 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

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21 January 2018

Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS.

1 reference

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21 January 2018

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

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21 January 2018

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1 reference

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21 January 2018

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

1 reference

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21 January 2018

Proliferation of human malignant astrocytomas is dependent on Ras activation.

1 reference

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21 January 2018

Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome

1 reference

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21 January 2018

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

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21 January 2018

Activation of the MAP kinase pathway by the protein kinase raf

1 reference

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21 January 2018

Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase

1 reference

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21 January 2018

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

1 reference

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21 January 2018

Bcl-2 and Bax function independently to regulate cell death

1 reference

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21 January 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203105

21 January 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

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21 January 2018

Raf-1 activates MAP kinase-kinase

1 reference

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21 January 2018

Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

1 reference

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21 January 2018

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

1 reference

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21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

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21 January 2018

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1 reference

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21 January 2018

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia

1 reference

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21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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21 January 2018

Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol

1 reference

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21 January 2018

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

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21 January 2018

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

1 reference

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21 January 2018

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

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21 January 2018

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

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21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

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21 January 2018

A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells

1 reference

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21 January 2018

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells

1 reference

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21 January 2018

Requirement for c-ras proteins during viral oncogene transformation

1 reference

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21 January 2018

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

1 reference

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21 January 2018

Expression of growth factor receptors in human brain tumours

1 reference

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21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

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21 January 2018

Structural alterations of the epidermal growth factor receptor gene in human gliomas

1 reference

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21 January 2018

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

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21 January 2018

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203105

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathways of Ras function: connections to the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203105

7 January 2021

based on heuristic

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Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1203105

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/10602510

ResearchGate publication ID

0 references

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