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Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants
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title
Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants
(English)
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author
Katja Lammens
object named as
Katja Lammens
series ordinal
2
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Charlotte Lässig
object named as
Charlotte Lässig
series ordinal
1
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Karl-Peter Hopfner
object named as
Karl-Peter Hopfner
series ordinal
6
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author name string
Jacob Lucián Gorenflos López
series ordinal
3
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Sebastian Michalski
series ordinal
4
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Olga Fettscher
series ordinal
5
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language of work or name
English
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publication date
26 July 2018
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published in
eLife
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volume
7
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cites work
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.
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Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.
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29 September 2018
Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
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29 September 2018
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
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29 September 2018
Further evidence for specific IFIH1 mutation as a cause of Singleton-Merten syndrome with phenotypic heterogeneity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
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PubMed Central
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29 September 2018
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Establishing the role of ATP for the function of the RIG-I innate immune sensor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
ATP-dependent effector-like functions of RIG-I-like receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency.
1 reference
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PubMed Central
reference URL
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29 September 2018
RIG-I ATPase activity and discrimination of self-RNA versus non-self-RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Aicardi-Goutières syndrome is caused by IFIH1 mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Parts, assembly and operation of the RIG-I family of motors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Defining the functional determinants for RNA surveillance by RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
NIH Image to ImageJ: 25 years of image analysis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
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29 September 2018
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Towards automated crystallographic structure refinement with phenix.refine
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Structural Insights into RNA Recognition by RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Overview of the CCP4 suite and current developments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
SF1 and SF2 helicases: family matters
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Features and development of Coot
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
XDS
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Phasercrystallographic software
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Baculovirus expression system for heterologous multiprotein complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6086658
retrieved
29 September 2018
Identifiers
DOI
10.7554/ELIFE.38958
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PMC publication ID
6086658
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PubMed publication ID
30047865
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