(Q56858071)

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Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9605313)

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8 July 2022

Defective MUTYH substrate processing

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9605313

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8 July 2022

MUTYH LOF mutants:(8oxoG:Ade)-dsDNA [nucleoplasm]

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8 July 2022

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations

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8 July 2022

Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis

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8 July 2022

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

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8 July 2022

Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer

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8 July 2022

Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells

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8 July 2022

Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer

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8 July 2022

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis

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8 July 2022

Characterization of mutant MUTYH proteins associated with familial colorectal cancer.

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8 July 2022

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

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8 July 2022

Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis

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8 July 2022

Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer

1 reference

8 July 2022

MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay.

1 reference

8 July 2022

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

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8 July 2022

Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma

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8 July 2022

Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymes

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8 July 2022

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q56858071)

Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine

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