(Q56860951)

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Transcriptional Regulation by MECP2

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8986944)

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Generic Transcription Pathway

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https://identifiers.org/reactome:R-HSA-8986944

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MECP2 binds the PVALB gene promoter

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PVALB gene expression is repressed by MECP2

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MECP2 binds GAMT gene promoter

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GAMT gene expression is stimulated by MECP2

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MECP2 binds SGK1 gene promoter

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SGK1 gene expression is inhibited by MECP2

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MECP2 binds MOBP gene promoter

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MOBP gene expression is inhibited by MECP2

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MECP2 and SOX2 bind MIR137 gene

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MIR137 gene expression is inhibited by MECP2 and SOX2

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miR-137 binds PTEN mRNA

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PTEN mRNA translation is inhibited by miR-137

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MECP2 binds IRAK1 gene

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IRAK1 gene expression is inhibited by MECP2

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Regulation of MECP2 expression and activity

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MECP2 regulates neuronal receptors and channels

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MECP2 regulates transcription of neuronal ligands

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MECP2 regulates transcription factors

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MECP2 regulates transcription of genes involved in GABA signaling

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Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor

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MeCP2, a key contributor to neurological disease, activates and represses transcription

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The major form of MeCP2 has a novel N-terminus generated by alternative splicing

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Reversal of neurological defects in a mouse model of Rett syndrome

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Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome

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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells

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MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex

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Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells

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GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells

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MECP2 promoter methylation and X chromosome inactivation in autism

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NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice

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Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

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Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome

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MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis

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A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome

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MECP2 Duplication Syndrome

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Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice

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Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

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N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso

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Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

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Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.

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PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

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Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS).

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Epigenetic transmission of the impact of early stress across generations.

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miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.

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Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

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Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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BDNF deregulation in Rett syndrome

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Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

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Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression

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Mutations in MECP2 exon 1 in classical Rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2.

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Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.

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Developmental Dynamics of Rett Syndrome

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Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1

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IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARγ gene in male and female rat lungs during alveolarization

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Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression

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Mecp2-null mice provide new neuronal targets for Rett syndrome.

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MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

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A role for glia in the progression of Rett's syndrome

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Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

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Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain.

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Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

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Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

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Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

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Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2

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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

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Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

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Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.

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The Rett syndrome protein MeCP2 regulates synaptic scaling

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

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Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

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Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons

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Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males

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Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

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MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function.

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Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

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Activity-dependent neuronal signalling and autism spectrum disorder

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Differential distribution of the MeCP2 splice variants in the postnatal mouse brain

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Identifiers

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(Q56860951)

Transcriptional Regulation by MECP2

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