(Q57007179)

7

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author name string

Okram Barun

1

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Stefan Sommer

3

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Anette Langerak

4

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Thomas U. Mayer

5

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Oliver Müller

European Journal of Organic Chemistry

6

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publication date

November 2005

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published in

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volume

2005

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issue

22

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page(s)

4773-4788

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cites work

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A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

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Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

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Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product

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A solid-supported, enantioselective synthesis suitable for the rapid preparation of large numbers of diverse structural analogues of (-)-saframycin A.

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Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy

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Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors

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Chemistry of spiroketals

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Antineoplastic agents. 257. Isolation and structure of spongistatin 1

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Okadaic acid: a new probe for the study of cellular regulation

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The structure and regulation of protein phosphatases

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Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase

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Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold

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Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1

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The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity

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Asymmetric solid-phase synthesis of 6,6-spiroketals

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Stereocontrolled synthesis of polyketide libraries: Boron-mediated aldol reactions with aldehydes on solid support

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A Combinatorial Approach to Polyketide-Type Libraries by Iterative Asymmetric Aldol Reactions Performed on Solid Support We thank the European Commission (TMR Network ERB-FMR XCT 96-0011 and IHP Network HPRN-CT-2000-00014), EPSRC, Pfizer, and Merck

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Total Synthesis of Siphonarin B and Dihydrosiphonarin B

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Total Synthesis of (-)-Ebelactone A and B

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Major effect of the leaving group in dialkylboron chlorides and triflates in controlling the stereospecific conversion of ketones into either [E]- or [Z]-enol borinates

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Stereoselective aldol reactions of chlorotitanium enolates. An efficient method for the assemblage of polypropionate-related synthons

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Origins of π-face selectivity in the aldol reactions of chiral E-enol borinates: a computational study using transition state modelling

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Bidirectional asymmetric allylboration. A convenient asymmetric synthesis of C(2)-symmetric 3-methylenepentane-1,5-diols and rapid access to C(2)-symmetric spiroketals

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The synthesis of deoxyfusapyrone. 2. Preparation of the bis-trisubstituted olefin fragment and its attachment to the pyrone moiety

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Highly enantioselective Alk-2-enylation of aldehydes through an allyl-transfer reaction

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The first and highly enantioselective crotylation of aldehydes via an allyl-transfer reaction from a chiral crotyl-donor

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Synthesis of the C16-C28 spiroketal subunit of spongistatin 1 (altohyrtin A): the pyrone approach

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An efficient synthesis of radicinin analogues

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Double Stereodifferentiating Aldol Reactions. The Documentation of "Partially Matched" Aldol Bond Constructions in the Assemblage of Polypropionate Systems

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Protein tyrosine phosphatases: prospects for therapeutics

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Protein tyrosine phosphatase 1B inhibitors for diabetes

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Inhibitors of protein tyrosine phosphatases: next-generation drugs?

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Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway

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Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition

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Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases

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Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue

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