(Q57181877)

2

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Benjamin J Orlando

3

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Nathan M Fastman

4

0 references

Jinru Zhang

5

0 references

Yan Xu

6

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Melissa G Chambers

7

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Xiaofang Xu

8

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Kay Perry

9

0 references

Maofu Liao

10

0 references

Liang Feng

11

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Benjamin J. Orlando

3

0 references

Nathan M. Fastman

4

0 references

Melissa G. Chambers

https://scigraph.springernature.com/pub.10.1038/s41586-018-0330-9

7

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language of work or name

English

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publication date

July 2018

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published in

Nature

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volume

559

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issue

7715

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page(s)

575-579

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exact match

0 references

cites work

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Enjoy the Trip: Calcium in Mitochondria Back and Forth

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Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

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Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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MCU encodes the pore conducting mitochondrial calcium currents

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Reconstitution of the mitochondrial calcium uniporter in yeast

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Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations

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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

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High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

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MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity

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EMRE is an essential component of the mitochondrial calcium uniporter complex

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Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

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Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

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MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

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Evolutionary diversity of the mitochondrial calcium uniporter

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Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease

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Architecture of the mitochondrial calcium uniporter

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A putative mitochondrial calcium uniporter in A. fumigatus contributes to mitochondrial Ca(2+) homeostasis and stress responses.

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A genetically targeted optical sensor to monitor calcium signals in astrocyte processes

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Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

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Structural analysis, identification, and design of calcium-binding sites in proteins

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Crystal structure of the epithelial calcium channel TRPV6

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Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.

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Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter

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Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

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Structure of the TRPV1 ion channel determined by electron cryo-microscopy

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

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7 January 2021

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

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7 January 2021

Structure of a mammalian ryanodine receptor

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Architecture and conformational switch mechanism of the ryanodine receptor

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Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

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Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

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Structure and symmetry inform gating principles of ionotropic glutamate receptors

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Preparation of selenomethionyl proteins for phase determination

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Lysine methylation as a routine rescue strategy for protein crystallization

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Yeast surface display platform for rapid discovery of conformationally selective nanobodies.

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Isolating and engineering human antibodies using yeast surface display

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Processing of X-ray diffraction data collected in oscillation mode

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Features and development of Coot

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MolProbity: all-atom structure validation for macromolecular crystallography

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Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2.

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7 January 2021

Quantitative measurements of membrane potential in Escherichia coli

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7 January 2021

Substrate recognition at the cytoplasmic and extracellular binding site of the lactose transport protein of Streptococcus thermophilus

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7 January 2021

Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle

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7 January 2021

Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage

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Automated electron microscope tomography using robust prediction of specimen movements

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7 January 2021

Structural basis of MsbA-mediated lipopolysaccharide transport

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Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

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A Bayesian view on cryo-EM structure determination.

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7 January 2021

Sampling the conformational space of the catalytic subunit of human γ-secretase

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7 January 2021

Quantifying the local resolution of cryo-EM density maps

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7 January 2021

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