(Q57252658)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30764037%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

Role of the growth hormone-IGF-1 axis in cancer (English)

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23 April 2020

1

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23 April 2020

Andrew J. Brooks

series ordinal

3

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23 April 2020

author name string

Michael J Waters

series ordinal

2

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23 April 2020

publication date

1 January 2011

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Expert review of endocrinology & metabolism

23 April 2020

published in

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23 April 2020

volume

6

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23 April 2020

issue

1

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23 April 2020

page(s)

71-84

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Normal growth and development in the absence of hepatic insulin-like growth factor I

23 April 2020

cites work

1 reference

Does growth hormone cause cancer?

21 January 2018

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

1 reference

Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

21 January 2018

1 reference

The question of a link between insulin-like growth factor physiology and neoplasia

21 January 2018

1 reference

The GH-IGF-I axis and breast cancer.

21 January 2018

1 reference

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

21 January 2018

1 reference

Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling

21 January 2018

1 reference

Growth hormone receptor; mechanism of action.

21 January 2018

1 reference

Height, leg length, and cancer risk: a systematic review

21 January 2018

1 reference

Serum and intratumoural GH and IGF-I concentrations: prognostic factors in the outcome of canine mammary cancer.

21 January 2018

1 reference

Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins

21 January 2018

1 reference

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

21 January 2018

1 reference

Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects

21 January 2018

1 reference

Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions

21 January 2018

1 reference

Variants in the GH-IGF axis confer susceptibility to lung cancer

21 January 2018

1 reference

Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade

21 January 2018

1 reference

Genetic Variation in the Growth Hormone Synthesis Pathway in Relation to Circulating Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and Breast Cancer Risk: Results from the European Prospective Investigation into Cancer a

21 January 2018

1 reference

IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort

21 January 2018

1 reference

Insulin-like growth factor polymorphisms and colorectal cancer risk.

21 January 2018

1 reference

Influence of IGFBP3 gene polymorphisms on IGFBP3 serum levels and the risk of prostate cancer in low-risk Korean men.

21 January 2018

1 reference

Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis

21 January 2018

1 reference

Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer

21 January 2018

1 reference

Acromegaly, growth hormone and cancer risk

21 January 2018

1 reference

Acromegaly: re-thinking the cancer risk

21 January 2018

1 reference

The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients.

21 January 2018

1 reference

Long-term safety of recombinant human growth hormone in children

21 January 2018

1 reference

High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice

21 January 2018

1 reference

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

21 January 2018

1 reference

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

21 January 2018

1 reference

Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation

21 January 2018

1 reference

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

21 January 2018

1 reference

Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo

21 January 2018

1 reference

Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling.

21 January 2018

1 reference

Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments

21 January 2018

1 reference

Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse

21 January 2018

1 reference

Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist

21 January 2018

1 reference

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

21 January 2018

1 reference

Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice

21 January 2018

1 reference

Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo

21 January 2018

1 reference

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice

21 January 2018

1 reference

Growth hormone receptor is expressed in human breast cancer

21 January 2018

1 reference

Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor

21 January 2018

1 reference

Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.

21 January 2018

1 reference

Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells

21 January 2018

1 reference

Growth hormone mRNA in mammary gland tumors of dogs and cats

21 January 2018

1 reference

Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17beta-estradiol) in canine mammary tumours.

21 January 2018

1 reference

Integrated gene networks in breast cancer development

21 January 2018

1 reference

Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system

21 January 2018

1 reference

Pit-1/GHF-1 and GH expression in the MCF-7 human breast adenocarcinoma cell line

21 January 2018

1 reference

Co-expression of GH and GHR isoforms in prostate cancer cell lines

21 January 2018

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Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients

21 January 2018

1 reference

Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17.

21 January 2018

1 reference

Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development

21 January 2018

1 reference

Zinc mediation of the binding of human growth hormone to the human prolactin receptor

21 January 2018

1 reference

Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma.

21 January 2018

1 reference

The contribution of growth hormone to mammary neoplasia

21 January 2018

1 reference

Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma

21 January 2018

1 reference

The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor

21 January 2018

1 reference

Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling

21 January 2018

1 reference

Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.

21 January 2018

1 reference

Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old.

21 January 2018

1 reference

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

21 January 2018

1 reference

The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation

21 January 2018

1 reference

Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers

21 January 2018

1 reference

Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

21 January 2018

1 reference

CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing

21 January 2018

1 reference

Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells

21 January 2018

1 reference

Complex prolactin crosstalk in breast cancer: new therapeutic implications

21 January 2018

1 reference

Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.

21 January 2018

1 reference

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

21 January 2018

1 reference

Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

21 January 2018

1 reference

Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell.

21 January 2018

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Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

21 January 2018

1 reference

STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone.

21 January 2018

1 reference

JAK-2 mutations and their relevance to myeloproliferative disease

21 January 2018

1 reference

A role for JAK2 mutations in myeloproliferative diseases

21 January 2018

1 reference

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

1 reference

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

1 reference

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

21 January 2018

1 reference

STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant

21 January 2018

1 reference

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

21 January 2018

1 reference

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

21 January 2018

1 reference

STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through SRC and JAK1 kinases

21 January 2018

1 reference

STAT5 contributes to antiapoptosis in melanoma.

21 January 2018

1 reference

Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition.

21 January 2018

1 reference

Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression

21 January 2018

1 reference

Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting

21 January 2018

1 reference

Cellular senescence in vivo: a barrier to tumorigenesis

21 January 2018

1 reference

Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence.

21 January 2018

1 reference

A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies.

21 January 2018

1 reference

Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma

21 January 2018

1 reference

Small-molecule cyclin-dependent kinase modulators

21 January 2018

1 reference

Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells

21 January 2018

1 reference

Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo

21 January 2018

1 reference

Mammary stem cell number as a determinate of breast cancer risk.

21 January 2018

1 reference

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

21 January 2018

1 reference

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

21 January 2018

1 reference

Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin

21 January 2018

1 reference

New concepts in prolactin biology

21 January 2018

1 reference

Growth hormone protects human lymphocytes from irradiation‐induced cell death

21 January 2018

1 reference

Growth hormone excess promotes breast cancer chemoresistance

21 January 2018

1 reference

Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice.

21 January 2018

1 reference

IGF-I andIGFBP-3 polymorphisms and risk of prostate cancer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EEM.10.73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30764037%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

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