(Q57362835)

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Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

scientific article published on 01 July 1998

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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Europe PubMed Central

Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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S N Sehgal

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

publication date

1 July 1998

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Clinical Biochemistry

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

31

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

5

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

335-340

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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New antitumor substances of natural origin

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Activity of rapamycin (AY-22,989) against transplanted tumors

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Inhibition of the immune response by rapamycin, a new antifungal antibiotic

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Rapamycin: a novel immunosuppressive macrolide

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7 January 2021

Rapamycin: in vitro profile of a new immunosuppressive macrolide

1 reference

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7 January 2021

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

1 reference

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7 January 2021

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

1 reference

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7 January 2021

Effects of cyclosporine and rapamycin on immunoglobulin production by preactivated human B cells

1 reference

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7 January 2021

Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion

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7 January 2021

Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

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7 January 2021

Effects of rapamycin on cultured hepatocyte proliferation and gene expression

1 reference

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7 January 2021

Antiproliferative effect of rapamycin on growth factor-stimulated human adult lung fibroblasts in vitro may explain its superior efficacy for prevention and treatment of allograft obliterative airway disease in vivo

1 reference

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7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

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7 January 2021

Rapamycin and FK506 binding proteins (immunophilins)

1 reference

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7 January 2021

Rapamycin: Biological and therapeutic effects, binding by immunophilins and molecular targets of action

1 reference

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7 January 2021

The immunophilins

1 reference

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7 January 2021

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

1 reference

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7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

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7 January 2021

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

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7 January 2021

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

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7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

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7 January 2021

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs

1 reference

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7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

1 reference

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7 January 2021

A Putative Sirolimus (Rapamycin) Effector Protein

1 reference

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

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7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

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7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

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7 January 2021

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

1 reference

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7 January 2021

Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast

1 reference

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7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

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7 January 2021

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

1 reference

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7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

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7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

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7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

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7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

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7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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7 January 2021

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

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7 January 2021

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

1 reference

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7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

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7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

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7 January 2021

A signaling pathway to translational control

1 reference

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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

1 reference

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7 January 2021

Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocyte. Evidence for inhibition of CREB/ATF binding activities

1 reference

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7 January 2021

Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells

1 reference

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7 January 2021

G1 phase progression: cycling on cue

1 reference

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7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

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7 January 2021

Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.

1 reference

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7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

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7 January 2021

Identifiers

10.1016/S0009-9120(98)00045-9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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