(Q57402000)

English

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

scientific article published on 19 October 2010

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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Anette P. Gjesing

1

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Europe PubMed Central

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15 February 2020

4

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Europe PubMed Central

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15 February 2020

Allan Linneberg

5

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Europe PubMed Central

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15 February 2020

Carolyn F. Deacon

6

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Europe PubMed Central

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15 February 2020

Jens Juul Holst

7

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Europe PubMed Central

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15 February 2020

Oluf Borbye Pedersen

8

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Europe PubMed Central

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15 February 2020

9

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Europe PubMed Central

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15 February 2020

author name string

L L Kjems

2

1 reference

Europe PubMed Central

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15 February 2020

M A Vestmar

3

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15 February 2020

publication date

19 October 2010

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Europe PubMed Central

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15 February 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

54

1 reference

Europe PubMed Central

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15 February 2020

1

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15 February 2020

103-110

1 reference

Europe PubMed Central

PubMed publication ID

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15 February 2020

https://scigraph.springernature.com/pub.10.1007/s00125-010-1940-4

0 references

Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Proglucagon-derived peptides: mechanisms of action and therapeutic potential

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Unraveling the science of incretin biology.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Islet specific Wnt activation in human type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translating TCF7L2: from gene to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ISEC: a program to calculate insulin secretion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, measurement, and secretion of human glucagon-like peptide-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT/beta-catenin increases the production of incretins by entero-endocrine cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific alternative splicing of TCF7L2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring pre-hepatic insulin secretion using a population model of C-peptide kinetics: accuracy and required sampling schedule.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-1940-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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