(Q57570872)

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Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

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scholarly article

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Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine (English)

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José das Neves

object named as

José das Neves

1

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object named as

Bruno Sarmento

7

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author name string

Johan Michiels

2

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Kevin K. Ariën

3

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Guido Vanham

4

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Mansoor Amiji

5

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Maria Fernanda Bahia

6

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publication date

10 November 2011

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Pharmaceutical Research

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29

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6

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1468-1484

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The spread, treatment, and prevention of HIV-1: evolution of a global pandemic

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Preexposure chemoprophylaxis for HIV prevention in men who have sex with men

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Microbicides and HIV prevention: lessons from the past, looking to the future

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

First real success for anti-HIV gel: a new start for HIV microbicides?

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Setting the stage: host invasion by HIV.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

HIV sexual transmission and microbicides

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Vaginal drug delivery systems for HIV prevention

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Nano-microbicides: challenges in drug delivery, patient ethics and intellectual property in the war against HIV/AIDS.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Nanoparticle-based vaginal drug delivery systems for HIV prevention

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Biodegradable poly(epsilon -caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

A vaginal fluid simulant

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Modeling HIV transfer between dendritic cells and T cells: importance of HIV phenotype, dendritic cell-T cell contact and T-cell activation

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Evaluation of in vitro proliferative activity of human fetal neural stem/progenitor cells using indirect measurements of viable cells based on cellular metabolic activity

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Measuring HIV neutralization in a luciferase reporter gene assay

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Antiviral compounds show enhanced activity in HIV-1 single cycle pseudovirus assays as compared to classical PBMC assays

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Poly-epsilon-caprolactone microspheres and nanospheres: an overview

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Regulated portals of entry into the cell

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Nanoparticle-cell interactions: drug delivery implications

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

In vitro pre- and post-exposure prophylaxis using HIV inhibitors as microbicides against cell-free or cell-associated HIV-1 infection

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Gels as vaginal drug delivery systems.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0622-3

21 January 2018

Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/22072053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22072053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of surfactants on the molecular aggregation of rhodamine dyes in aqueous solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22072053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22072053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-011-0622-3

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