(Q57693482)

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The role of matrix metalloproteinases in the pathophysiology and progression of human nervous system malignancies: a chance for the development of targeted therapeutic approaches?

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Europe PubMed Central

The role of matrix metalloproteinases in the pathophysiology and progression of human nervous system malignancies: a chance for the development of targeted therapeutic approaches? (English)

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pathophysiology

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based on heuristic

inferred from title

Apostolos Zarros

object named as

Apostolos Zarros

2

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Stamatios Theocharis

3

object named as

Stamatios Theocharis

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author name string

Ioannis Koutroulis

1

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language of work or name

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publication date

13 November 2008

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Expert Opinion on Therapeutic Targets

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12

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12

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1577-1586

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

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Matrix metalloproteinases: useful and deleterious

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Zinc-binding groups modulate selective inhibition of MMPs

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21 January 2018

Matrix metalloproteinases

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21 January 2018

How matrix metalloproteinases regulate cell behavior

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21 January 2018

Extracellular matrix degradation by metalloproteinases and central nervous system diseases

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21 January 2018

The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells

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Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis

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Structure and function of matrix metalloproteinases and TIMPs

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21 January 2018

Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

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21 January 2018

Metalloproteinases in biology and pathology of the nervous system.

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Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets

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Metalloproteinases: mediators of pathology and regeneration in the CNS.

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Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.

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21 January 2018

MMPs in the central nervous system: where the good guys go bad.

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Molecular mechanisms of glioma cell migration and invasion

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Matrix metalloproteinases in tumor invasion and metastasis

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Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.

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Malignant gliomas

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Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas.

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21 January 2018

Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion

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Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.

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High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma.

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21 January 2018

Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo.

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Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo

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Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas

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https://api.crossref.org/works/10.1517%2F14728220802560307

21 January 2018

Expression of matrix metalloproteinases and their inhibitors in human brain tumors.

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21 January 2018

Expression of serine proteases and metalloproteinases in human pituitary adenomas and anterior pituitary lobe tissue

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21 January 2018

Role of matrix metalloproteinase 9 in pituitary tumor behavior

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21 January 2018

Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion.

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21 January 2018

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

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21 January 2018

Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro

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21 January 2018

Enhancement of pituitary adenoma cell invasion and adhesion is mediated by discoidin domain receptor-1.

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Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.

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Differential expression of laminin and fibronectin and of their related metalloproteinases in human glioma cell lines: relation to invasion.

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The TIMPs tango with MMPs and more in the central nervous system

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21 January 2018

Natural bio-drugs as matrix metalloproteinase inhibitors: new perspectives on the horizon?

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Influence of VEGF-R2 inhibition on MMP secretion and motility of microvascular human cerebral endothelial cells (HCEC).

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Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model

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Modulation of proteolytic potential and differentiation by CNTF and BDNF in two mouse neuroblastoma clones: relation to invasion.

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Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2

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Suppression of cell invasion on human malignant glioma cell lines by a novel matrix-metalloproteinase inhibitor SI-27: in vitro study.

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Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat

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Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.

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Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme

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Phase II study of high central dose Gamma Knife radiosurgery and marimastat in patients with recurrent malignant glioma

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Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

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Randomized, double-blind, placebo-controlled trial of marimastat in glioblastoma multiforme patients following surgery and irradiation.

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Hyperthermia exhibits anti-vascular activity in the s.c. BT4An rat glioma: lack of interaction with the angiogenesis inhibitor batimastat

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The other side of MMPs: protective roles in tumor progression

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MMPs as therapeutic targets--still a viable option?

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Clinical potential of matrix metalloprotease inhibitors in cancer therapy

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10.1517/14728220802560307

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