(Q57697033)

7

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author name string

Qian Yang

1

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David Fedida

2

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Hongjian Xu

3

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Lupei Du

5

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Xiaojian Wang

6

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Qidong You

Drug discoveries towards Kv1.5 potassium channel

8

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publication date

10 June 2010

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published in

ChemMedChem

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volume

5

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issue

8

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page(s)

1353-1358

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cites work

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Acute management of atrial fibrillation

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New horizons in antiarrhythmic therapy: will novel agents overcome current deficits?

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Management of atrial fibrillation

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Drug discovery for heart failure: a new era or the end of the pipeline?

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Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents, and innovative approaches

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A benefit-risk assessment of class III antiarrhythmic agents

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Strategies for atrial fibrillation therapy: focusing onIKurpotassium channel

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Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents

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Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation

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Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?

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The moving parts of voltage-gated ion channels

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Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.

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Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels

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Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation

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Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

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Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias

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Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

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Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers

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Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

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Inhibition by a novel anti-arrhythmic agent, NIP-142, of cloned human cardiac K+ channel Kv1.5 current

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Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter

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RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents

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The mechanism of atrial antiarrhythmic action of RSD1235.

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7 January 2021

Vernakalant: RSD 1235, RSD-1235, RSD1235

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Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent

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A randomized, controlled trial of RSD1235, a novel anti-arrhythmic agent, in the treatment of recent onset atrial fibrillation

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The effect of vernakalant (RSD1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humans

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Atrial fibrillation: from ion channels to bedside treatment options

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Modeling the binding modes of Kv1.5 potassium channel and blockers

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Structure-Based Discovery and Experimental Verification of Novel AI-2 Quorum Sensing Inhibitors againstVibrio harveyi

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Comparison of consensus scoring strategies for evaluating computational models of protein-ligand complexes

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Detailed analysis of scoring functions for virtual screening

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7 January 2021

Gaussian docking functions

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7 January 2021

Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers

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7 January 2021

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The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells

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7 January 2021

The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels

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7 January 2021