(Q57835915)

Christopher A. MacRaild

4

0 references

Peter J. Scammells

Peter J. Scammells

11

0 references

Robin Fredric Anders

8

Robin F. Anders

0 references

Raymond Norton

12

Raymond S. Norton

0 references

author name string

Shane M. Devine

1

0 references

San Sui Lim

2

0 references

Indu R. Chandrashekaran

3

0 references

Damien R. Drew

5

0 references

Cael O. Debono

6

0 references

James G. Beeson

9

0 references

Martin J. Scanlon

The pathogenic basis of malaria

10

0 references

publication date

2014

0 references

published in

MedChemComm

0 references

volume

5

0 references

issue

10

0 references

page(s)

1500-1506

0 references

cites work

1 reference

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Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

21 January 2018

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The global pipeline of new medicines for the control and elimination of malaria

21 January 2018

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Recent advances in malaria drug discovery

21 January 2018

1 reference

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Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Dissecting the apicomplexan rhoptry neck proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Apical membrane antigen 1 as an anti-malarial drug target

21 January 2018

1 reference

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New targets for drug discovery against malaria

21 January 2018

1 reference

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Transporters as mediators of drug resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

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Assessing the lipophilicity of fragments and early hits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Learning from our mistakes: the 'unknown knowns' in fragment screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MD00090K