(Q57903651)

English

The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth

article

In more languages

default values for all languages

No label defined

No description defined

Statements

scholarly article

0 references

The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth (English)

0 references

1 reference

based on heuristic

inferred from title

Julian Downward

object named as

Julian Downward

4

0 references

author name string

Margaret Ashcroft

1

0 references

Robert M Stephens

2

0 references

Bengt Hallberg

3

0 references

David R Kaplan

5

0 references

language of work or name

0 references

publication date

August 1999

0 references

0 references

18

0 references

32

0 references

4586-4597

0 references

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

21 January 2018

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

A target for Pl(3) kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by the neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of novel substrates of Trk receptors in developing neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular signaling pathways activated by neurotrophic factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin 3-dependent survival by the Akt protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202814

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1202814

0 references

PubMed publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q57903651&oldid=2213669512"