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Hypertension linked to PDE3A activation

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title

Hypertension linked to PDE3A activation (English)

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Miles Houslay

1

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language of work or name

English

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publication date

June 2015

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published in

Nature Genetics

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volume

47

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issue

6

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page(s)

562-563

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exact match

https://scigraph.springernature.com/pub.10.1038/ng.3316

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cites work

PDE3A mutations cause autosomal dominant hypertension with brachydactyly

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21 January 2018

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

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21 January 2018

Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction

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21 January 2018

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

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21 January 2018

Platelet antiaggregants in stroke prevention

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

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Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms

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21 January 2018

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

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Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

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21 January 2018

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

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21 January 2018

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation

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21 January 2018

Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke

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Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis.

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Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.

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Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4

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retrieved

7 January 2021

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Hypertension linked to PDE3A activation

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