(Q57980185)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14764585%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

title

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1 (English)

1 reference

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18 November 2019

5

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18 November 2019

Victor Tybulewicz

6

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18 November 2019

author name string

Carine de Bettignies

2

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18 November 2019

Trisha Norton

3

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18 November 2019

Alexander Beeser

4

1 reference

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18 November 2019

Lucinda F Reynolds

1

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18 November 2019

language of work or name

English

0 references

publication date

5 February 2004

1 reference

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Journal of Biological Chemistry

18 November 2019

published in

1 reference

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18 November 2019

volume

279

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18 November 2019

issue

18

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18 November 2019

page(s)

18239-18246

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Positive and negative selection of T cells

18 November 2019

cites work

1 reference

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Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

21 January 2018

1 reference

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Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

21 January 2018

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Proto-vav and gene expression.

21 January 2018

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

21 January 2018

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

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Lck regulates Vav activation of members of the Rho family of GTPases

21 January 2018

1 reference

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

21 January 2018

1 reference

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

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Vav regulates peptide-specific apoptosis in thymocytes

21 January 2018

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

1 reference

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

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Selective requirement for MAP kinase activation in thymocyte differentiation.

21 January 2018

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Positive and negative selection invoke distinct signaling pathways.

21 January 2018

1 reference

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

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MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.

21 January 2018

1 reference

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Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

21 January 2018

1 reference

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Transduction of full-length Tat fusion proteins directly into mammalian cells: analysis of T cell receptor activation-induced cell death

21 January 2018

1 reference

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Cell cycle-dependent activation of Ras.

21 January 2018

1 reference

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

1 reference

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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

21 January 2018

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

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The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

21 January 2018

1 reference

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Modulation of cellular function by TAT mediated transduction of full length proteins

21 January 2018

1 reference

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Regulation of RasGRP via a phorbol ester-responsive C1 domain.

21 January 2018

1 reference

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

The extended protein kinase C superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Protein kinase D: an intracellular traffic regulator on the move

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Protein kinase D is a downstream target of protein kinase Ctheta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

21 January 2018

1 reference

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

1 reference

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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Role of zeta PKC in B-cell signaling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Raf regulates positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400257200

21 January 2018

Identifiers

DOI

10.1074/JBC.M400257200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14764585%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

1 reference