(Q34718119)

4 August 2017

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title

VAV proteins as signal integrators for multi-subunit immune-recognition receptors (English)

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4 August 2017

Martin Turner

1

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PubMed ID

12094222

4 August 2017

Daniel D Billadeau

series ordinal

2

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4 August 2017

1 July 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

7

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4 August 2017

476-486

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Rho GTPases and their effector proteins

4 August 2017

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Vav proteins, adaptors and cell signaling.

31 March 2020

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Small GTPases in lymphocyte biology: Rho proteins take center stage

31 March 2020

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

31 March 2020

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Lck regulates Vav activation of members of the Rho family of GTPases

31 March 2020

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

31 March 2020

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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

31 March 2020

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T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase

31 March 2020

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

31 March 2020

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Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

31 March 2020

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Specific subdomains of Vav differentially affect T cell and NK cell activation

31 March 2020

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A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation

31 March 2020

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Regulatory and signaling properties of the Vav family

31 March 2020

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Positive and negative regulation of T-cell activation by adaptor proteins

31 March 2020

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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

31 March 2020

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Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte

31 March 2020

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Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation

31 March 2020

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Differential requirement for SLP-76 domains in T cell development and function

31 March 2020

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The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

31 March 2020

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Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.

31 March 2020

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Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription

31 March 2020

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CD28 Signaling via VAV/SLP-76 Adaptors

31 March 2020

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CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

31 March 2020

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Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes

31 March 2020

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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

31 March 2020

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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

31 March 2020

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

31 March 2020

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Binding of Vav to Grb2 through dimerization of Src homology 3 domains

31 March 2020

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Novel recognition mode between Vav and Grb2 SH3 domains

31 March 2020

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Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

31 March 2020

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Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

31 March 2020

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

31 March 2020

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

31 March 2020

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Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells

31 March 2020

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

31 March 2020

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The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity

31 March 2020

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A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

31 March 2020

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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

31 March 2020

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Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

31 March 2020

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

31 March 2020

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Dbl family guanine nucleotide exchange factors

31 March 2020

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The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

31 March 2020

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

31 March 2020

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Antibody regulation of B cell development

31 March 2020

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Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

31 March 2020

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Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

31 March 2020

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Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor.

31 March 2020

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

31 March 2020

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

31 March 2020

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Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

31 March 2020

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Early alpha beta T cell development in the thymus of normal and genetically altered mice

31 March 2020

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

31 March 2020

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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

31 March 2020

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Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

31 March 2020

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Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo

31 March 2020

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

31 March 2020

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Vav-1 regulates NK T cell development and NK cell cytotoxicity

31 March 2020

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

31 March 2020

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

31 March 2020

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Vav regulates peptide-specific apoptosis in thymocytes

31 March 2020

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Vav family proteins couple to diverse cell surface receptors

31 March 2020

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

31 March 2020

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The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

31 March 2020

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Regulation of the natural killer cell receptor repertoire

31 March 2020

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Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

31 March 2020

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Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

31 March 2020

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Roles of mast cells and basophils in innate and acquired immunity

31 March 2020

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

31 March 2020

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Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

31 March 2020

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Vav2 is an activator of Cdc42, Rac1, and RhoA

31 March 2020

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Vav2 is required for cell spreading

31 March 2020

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How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42.

31 March 2020

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

31 March 2020

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The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

31 March 2020

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Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

31 March 2020

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T cell receptor signaling precedes immunological synapse formation

31 March 2020

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Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter

31 March 2020

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A functional T-cell receptor signaling pathway is required for p95vav activity

31 March 2020

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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

31 March 2020

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Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

31 March 2020

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Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

31 March 2020

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

31 March 2020

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The role of calcineurin in lymphocyte activation

31 March 2020

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Rho family GTPases bind to phosphoinositide kinases

31 March 2020

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In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

31 March 2020

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Tec kinases: modulators of lymphocyte signaling and development

31 March 2020

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Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

31 March 2020

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Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells

31 March 2020

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Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

31 March 2020

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Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

31 March 2020

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IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases

31 March 2020

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The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS

31 March 2020

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Identification of Itk/Tsk Src homology 3 domain ligands

31 March 2020

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Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

31 March 2020

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Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

31 March 2020

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N-terminally truncated Vav induces the formation of depolymerization-resistant actin filaments in NIH 3T3 cells

31 March 2020

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Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors

31 March 2020

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Xid-like phenotypes: a B cell signalosome takes shape

31 March 2020

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Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

31 March 2020

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Vav and the B cell signalosome

31 March 2020

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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

31 March 2020

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

31 March 2020

1 reference

https://api.fatcat.wiki/v0/release/f2rundrol5fzlfeilbryq7ufaq

31 March 2020

Identifiers

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