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The Molecular Anatomy of Integrins
article published in 1999
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scholarly article
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title
The Molecular Anatomy of Integrins
(English)
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author name string
Linda J. Green
series ordinal
1
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Martin J. Humphries
series ordinal
2
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publication date
1999
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published in
Advances in Molecular and Cell Biology
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page(s)
3-26
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cites work
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization
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A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing
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A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro
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Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18)
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Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit
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Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium
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Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family
1 reference
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Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia
1 reference
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Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin
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Integrin cytoplasmic interactions and bidirectional transmembrane signalling
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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
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Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding
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A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin
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Dynamic regulation of integrins
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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A novel activating anti-beta1 integrin monoclonal antibody binds to the cysteine-rich repeats in the beta1 chain
1 reference
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reference URL
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7 January 2021
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Proteolytic processing of endogenous and recombinant beta 4 integrin subunit
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7 January 2021
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inferred from DOI database lookup
Inside-out integrin signalling
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7 January 2021
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Identifying the putative metal ion-dependent adhesion site in the beta2 (CD18) subunit required for alphaLbeta2 and alphaMbeta2 ligand interactions
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7 January 2021
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Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit
1 reference
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7 January 2021
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Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit
1 reference
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reference URL
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7 January 2021
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The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
1 reference
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7 January 2021
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Breaking the integrin hinge. A defined structural constraint regulates integrin signaling
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7 January 2021
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The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.
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Integrin activation: the link between ligand binding and signal transduction
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Integrins: versatility, modulation, and signaling in cell adhesion
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Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.
1 reference
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Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution
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Signal transduction from the extracellular matrix
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Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)
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Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin
1 reference
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Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1
1 reference
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Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes
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The structural bases of integrin-ligand interactions
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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
1 reference
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Two conformations of the integrin A-domain (I-domain): a pathway for activation?
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The amino-terminal one-third of alpha IIb defines the ligand recognition specificity of integrin alpha IIb beta 3.
1 reference
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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation
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The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions
1 reference
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Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin
1 reference
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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
1 reference
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Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.
1 reference
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inferred from DOI database lookup
The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy
1 reference
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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies
1 reference
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inferred from DOI database lookup
Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit
1 reference
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Crossref
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7 January 2021
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α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1
1 reference
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reference URL
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7 January 2021
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Integrin adhesion receptors: structure, function and implications for biomedicine
1 reference
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7 January 2021
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inferred from DOI database lookup
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin cytoplasmic domains mediate inside-out signal transduction
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb
1 reference
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7 January 2021
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inferred from DOI database lookup
Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Variants of the cell recognition site of fibronectin that retain attachment-promoting activity
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Critical residues for ligand binding in an I domain-like structure of the integrin beta1 subunit.
1 reference
stated in
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
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Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Integrins and their ligands.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structures of the helix-loop-helix calcium-binding proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
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A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternative cytoplasmic domain of the integrin beta 3 subunit
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
The inner world of cell adhesion: integrin cytoplasmic domains
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
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inferred from DOI database lookup
Amino acid sequence specificities of an adhesive recognition signal
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
based on heuristic
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Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960042-9
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7 January 2021
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10.1016/S1569-2558(08)60042-9
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