(Q58293268)

1

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Russell Naven

2

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Arjun Narayanan

3

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Yvonne Will

4

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Lyn H. Jones

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

5

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publication date

2013

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published in

MedChemComm

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volume

4

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issue

8

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page(s)

1175

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cites work

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Chemistry and biology of biomolecule nitration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Physicochemical drug properties associated with in vivo toxicological outcomes: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Role of quinones in toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

The enigmatic reaction of flavins with oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Oxidation-reduction potentials of toxoflavin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Cytotoxicity testing: measuring viable cells, dead cells, and detecting mechanism of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

The primary cytotoxicity in ultraviolet-a-irradiated riboflavin solution is derived from hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Phototoxicity and photogenotoxicity of nine pyridone derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Photoinduced redox cycle of riboflavin at a water/oil interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Reduction and uptake of methylene blue by human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

The role of pyocyanin in Pseudomonas aeruginosa infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Cell death from antibiotics without the involvement of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Production of superoxide radical in reductive metabolism of a synthetic food-coloring agent, indigocarmine, and related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Heteroaromatic rings of the future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Cyclic denaturation and renaturation of double-stranded DNA by redox-state switching of DNA intercalators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Flavin-cyclodextrin conjugates as catalysts of enantioselective sulfoxidations with hydrogen peroxide in aqueous media

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Amplified and in situ detection of redox-active metabolite using a biobased redox capacitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Developing irreversible inhibitors of the protein kinase cysteinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Irreversible Nek2 kinase inhibitors with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K

Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00149K