(Q58866835)

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Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences

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31 December 2019

Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences (English)

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31 December 2019

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31 December 2019

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31 December 2019

Rachele Cagliani

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Rachele Cagliani

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ORCID Public Data File 2021

Giorgia Menozzi

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Giorgia Menozzi

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21 July 2005

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31 December 2019

Human Molecular Genetics

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31 December 2019

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31 December 2019

2533-2546

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31 December 2019

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Conserved non-genic sequences - an unexpected feature of mammalian genomes

1 reference

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21 January 2018

Comparative genomics at the vertebrate extremes

1 reference

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21 January 2018

Ultraconserved Elements in the Human Genome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Phylogenetic shadowing of primate sequences to find functional regions of the human genome

1 reference

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21 January 2018

Scanning Human Gene Deserts for Long-Range Enhancers

1 reference

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21 January 2018

Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

rVISTA 2.0: evolutionary analysis of transcription factor binding sites

1 reference

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21 January 2018

Evolution and functional classification of vertebrate gene deserts

1 reference

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21 January 2018

Intronic sequences flanking alternatively spliced exons are conserved between human and mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment

1 reference

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21 January 2018

Combining phylogenetic and hidden Markov models in biosequence analysis

1 reference

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21 January 2018

Phylogenetic estimation of context-dependent substitution rates by maximum likelihood

1 reference

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21 January 2018

Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation

1 reference

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21 January 2018

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents

1 reference

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21 January 2018

Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene

1 reference

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21 January 2018

A novel bipartite intronic splicing enhancer promotes the inclusion of a mini-exon in the AMP deaminase 1 gene

1 reference

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21 January 2018

NF-κB RegulatesBCL3Transcription in T Lymphocytes Through an Intronic Enhancer

1 reference

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21 January 2018

Characterization of mutations, including a novel regulatory defect in the first intron, in Bruton's tyrosine kinase gene from seven Korean X-linked agammaglobulinemia families.

1 reference

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21 January 2018

An intron enhancer containing a 5' splice site sequence in the human calcitonin/calcitonin gene-related peptide gene

1 reference

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21 January 2018

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

1 reference

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21 January 2018

A regulatory element in intron 1 of the cystic fibrosis transmembrane conductance regulator gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Splicing Factors Induce Cystic Fibrosis Transmembrane Regulator Exon 9 Skipping through a Nonevolutionary Conserved Intronic Element

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

A muscle-specific enhancer within intron 1 of the human dystrophin gene is functionally dependent on single MEF-1/E box and MEF-2/AT-rich sequence motifs

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Redundant intronic repressors function to inhibit fibroblast growth factor receptor-1 alpha-exon recognition in glioblastoma cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Regulation of the human high affinity IgE receptor beta-chain gene expression via an intronic element

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Transcriptional regulation of the human nonmuscle myosin II heavy chain-A gene. Identification of three clustered cis-elements in intron-1 which modulate transcription in a cell type- and differentiation state-dependent manner

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

1 reference

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21 January 2018

A PLP splicing abnormality is associated with an unusual presentation of PMD.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Identification of an intronic regulatory element in the human protein C ( PROC) gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Transcriptional Control of the Human Sodium-coupled Neutral Amino Acid Transporter System A Gene by Amino Acid Availability Is Mediated by an Intronic Element

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Identification of a cis-acting element for the regulation of SMN exon 7 splicing

1 reference

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21 January 2018

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.

1 reference

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21 January 2018

RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Utrophin transcription is activated by an intronic enhancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

GeneMerge—post-genomic analysis, data mining, and hypothesis testing

1 reference

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21 January 2018

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters

1 reference

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21 January 2018

Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

1 reference

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21 January 2018

Isochores and tissue-specificity

1 reference

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21 January 2018

Highly conserved upstream sequences for transcription factor genes and implications for the regulatory network

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Identification and analysis of alternative splicing events conserved in human and mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Non-coding RNAs: the architects of eukaryotic complexity

1 reference

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21 January 2018

Alternative pre-mRNA splicing and proteome expansion in metazoans

1 reference

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21 January 2018

Splicing is required for rapid and efficient mRNA export in metazoans

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Selection for short introns in highly expressed genes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Compactness of human housekeeping genes: selection for economy or genomic design?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Fixation of conserved sequences shapes human intron size and influences transposon-insertion dynamics

1 reference

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21 January 2018

A functional role for some Fugu introns larger than the typical short ones: the example of the gene coding for ribosomal protein S7 and snoRNA U17.

1 reference

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21 January 2018

Comparative Analysis of Vertebrate Dystrophin Loci Indicate Intron Gigantism as a Common Feature

1 reference

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21 January 2018

A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Low conservation of alternative splicing patterns in the human and mouse genomes.

1 reference

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21 January 2018

In search of the vertebrate phylotypic stage: a molecular examination of the developmental hourglass model and von Baer's third law.

1 reference

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21 January 2018

The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint

1 reference

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21 January 2018

cis-Regulatory and protein evolution in orthologous and duplicate genes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Mammalian housekeeping genes evolve more slowly than tissue-specific genes.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Gene expression intensity shapes evolutionary rates of the proteins encoded by the vertebrate genome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI257

21 January 2018

Elevated rates of protein secretion, evolution, and disease among tissue-specific genes

1 reference

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21 January 2018

Genome-wide identification of genes likely to be involved in human genetic disease

1 reference

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21 January 2018

A gene atlas of the mouse and human protein-encoding transcriptomes

1 reference

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21 January 2018

Large-scale analysis of the human and mouse transcriptomes

1 reference

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21 January 2018

Identifiers

10.1093/HMG/DDI257

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16037065%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16037065%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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