(Q59614741)

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Endogenous interleukin-6 amplifies interleukin-17 production and corticoid-resistance in peripheral T cells from patients with multiple sclerosis

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scholarly article

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Endogenous interleukin-6 amplifies interleukin-17 production and corticoid-resistance in peripheral T cells from patients with multiple sclerosis (English)

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multiple sclerosis

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based on heuristic

inferred from title

Ana Cristina Wing

object named as

Ana Cristina Wing

10

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Priscila O. Barros

object named as

Priscila O Barros

3

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author name string

Thais B Ferreira

1

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Joana Hygino

2

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Bruna Teixeira

4

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Taissa M Kasahara

5

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Ulisses C Linhares

6

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Lana Márcia F Lopes

7

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Claudia Cristina F Vasconcelos

8

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Regina Alvarenga

9

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Regis M Andrade

11

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Arnaldo F B Andrade

12

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Cleonice A M Bento

13

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language of work or name

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publication date

December 2014

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143

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4

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560-8

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The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic development of glucocorticoid resistance during autoimmune neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low sensitivity to glucocorticoid inhibition of in vitro Th17-related cytokine production in multiple sclerosis patients is related to elevated plasma lipopolysaccharide levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids in T cell development and function*.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB activation pathways induced by T cell costimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis: evidence for immunopathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to and production of interleukin 2 by peripheral blood and cerebrospinal fluid lymphocytes of patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6 activates heat-shock protein 90 beta gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unregulated IL-23/IL-17 immune response in autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/24919524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/IMM.12334

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