(Q59921945)

English

Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian L

scientific article published on 08 August 2013

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scholarly article

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12 March 2020

Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian LPS sensor system (English)

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12 March 2020

toll-like receptor

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1

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12 March 2020

author name string

Jorge Lozano-Aponte

2

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12 March 2020

Vianihuini Figueroa-Vazquez

3

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12 March 2020

Julian A Yunes-Rojas

4

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12 March 2020

Ulrich Zähringer

5

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12 March 2020

Christian Alexander

6

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12 March 2020

language of work or name

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publication date

8 August 2013

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12 March 2020

Computational and Structural Biotechnology Journal

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12 March 2020

7

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12 March 2020

9

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e201305003

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688739%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

The molecular basis of the host response to lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docking and scoring--theoretically easy, practically impossible?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial lipopolysaccharides and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E5531, a pure endotoxin antagonist of high potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGA: a versatile program to convert, handle and visualize molecular structure on Windows-based PCs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-endotoxin activity of a novel synthetic lipid A analog

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modified AutoDock for accurate docking of protein kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved prediction of protein side-chain conformations with SCWRL4

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions with aromatic rings in chemical and biological recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clustal W and Clustal X version 2.0

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of soluble MD-1 and its interaction with lipid IVa

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attractive intramolecular edge-to-face aromatic interactions in flexible organic molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/24688739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.5936/CSBJ.201305003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688739%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688739%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688739%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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