Wikidata

(Q6103521)

English

NFKB inhibitor alpha

mammalian protein found in Homo sapiens

  • NF-kappa-B inhibitor alpha
  • ikB-alpha
  • I-kappa-B-alpha
  • IkappaBalpha
  • NFKBIA
  • major histocompatibility complex enhancer-binding protein MAD3
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
  • nuclear factor of kappa light chain gene enhancer in B-cells
  • NF-KappaB Inhibitor alpha
In more languages

Statements

molecular function
protein binding
determination method
IPI
55 references
retrieved
8 April 2019
stated in
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
GOA
curator
UniProt
UniProt protein ID
P25963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
In silico structural and functional characterization of the RSUME splice variants
GOA
curator
UniProt
UniProt protein ID
P25963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
GOA
curator
UniProt
UniProt protein ID
P25963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages
GOA
curator
UniProt
UniProt protein ID
P25963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
UniProt
UniProt protein ID
P25963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
DDRGK1 regulates NF-κB activity by modulating IκBα stability
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of inhibitor of κB kinase β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3 interacts with the NF-κB inhibitor IκBα
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Structure of an IkappaBalpha/NF-kappaB complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Binding of manumycin A inhibits IkappaB kinase beta activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
COMMD proteins, a novel family of structural and functional homologs of MURR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
retrieved
8 April 2019
stated in
The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE NFKBIA 201502 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D000072000
subject named as
NF-KappaB Inhibitor alpha
0 references
 
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