(Q61051287)

English

Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA c

article published in 2010

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scholarly article

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Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA c (English)

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dyskeratosis congenita

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Aloysius J. Klingelhutz

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Aloysius J Klingelhutz

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Francoise A Gourronc

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mckaylee M Robertson

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Annie K Herrig

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Peter M Lansdorp

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Frederick D Goldman

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publication date

March 2010

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Experimental Dermatology

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19

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3

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279-88

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Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Conditional telomerase induction causes proliferation of hair follicle stem cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Effects of telomerase and telomere length on epidermal stem cell behavior

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere length homeostasis requires that telomerase levels are limiting

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Adenoviral human telomerase reverse transcriptase dramatically improves ischemic wound healing without detrimental immune response in an aged rabbit model

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere-related genome instability in cancer.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomeres rather than telomerase a key target for anti-cancer therapy?

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere homolog oligonucleotides and the skin: current status and future perspectives

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Epidermal stem cells are resistant to cellular aging

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Dysfunctional telomeres and dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Dyskeratosis congenita: a genetic disorder of many faces

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase and cancer therapeutics

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomeres and aging

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Late manifestation of dyskeratosis congenita presenting as chronic dermal ulcer in a 37-year-old man

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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A telomerase component is defective in the human disease dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Dyskeratosis congenita in all its forms

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase in the human organism

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Cervical epithelial cells transduced with the papillomavirus E6/E7 oncogenes maintain stable levels of oncoprotein expression but exhibit progressive, major increases in hTERT gene expression and telomerase activity

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Design of HIV vectors for efficient gene delivery into human hematopoietic cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere shortening in cultured autografts of patients with burns

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Dyskeratosis congenita: its link to telomerase and aplastic anaemia

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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The role of telomeres in skin aging/photoaging

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomere shortening is associated with cell division in vitro and in vivo

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activity in normal and malignant hematopoietic cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activation by the E6 gene product of human papillomavirus type 16.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activity in human germline and embryonic tissues and cells.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Telomerase activity concentrates in the mitotically active segments of human hair follicles

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Extension of life-span by introduction of telomerase into normal human cells

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

based on heuristic

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A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

based on heuristic

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Cutaneous wound healing

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Skin aging: a role for telomerase and telomere dynamics?

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https://pubmed.ncbi.nlm.nih.gov/19558498

12 December 2020

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Identifiers

10.1111/J.1600-0625.2009.00916.X

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