(Q61061795)

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A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation

scientific article published on 26 April 2015

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scholarly article

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Europe PubMed Central

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6 March 2020

A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation (English)

1 reference

Europe PubMed Central

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6 March 2020

lung metastasis

1 reference

based on heuristic

inferred from title

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Aaron Babendreyer

4

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6 March 2020

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6 March 2020

Daniela Dreymueller

11

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author name string

Tobias Pasqualon

1

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6 March 2020

Jessica Pruessmeyer

2

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6 March 2020

Sarah Weidenfeld

3

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6 March 2020

Esther Groth

5

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6 March 2020

Julian Schumacher

6

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6 March 2020

Bernd Denecke

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6 March 2020

Pascale Zimmermann

10

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6 March 2020

publication date

26 April 2015

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6 March 2020

Cellular and Molecular Life Sciences

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6 March 2020

72

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19

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6 March 2020

3783-3801

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6 March 2020

https://scigraph.springernature.com/pub.10.1007/s00018-015-1912-4

0 references

Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecans play dual roles as cell adhesion receptors and docking receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genecentric Human Protein Atlas for expression profiles based on antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecans: new kids on the signaling block

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular functions of syndecan-1 in disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated shedding of syndecan ectodomains by chemokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteoglycans in health and disease: the multiple roles of syndecan shedding

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shedding of cell membrane-bound proteoglycans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focal adhesion kinase: in command and control of cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods for detection of circulating cells in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan signaling: when, where and why?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular mechanisms of syndecans in tissue injury and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases control polarity, protrusion, and adhesion during cell movement

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecans as cell surface receptors: Unique structure equates with functional diversity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sdc1 overexpression inhibits the p38 MAPK pathway and lessens fibrotic ventricular remodeling in MI rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan-1-mediated cell spreading requires signaling by αvβ3 integrins in human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum syndecan-1: a new independent prognostic marker in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25912030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-015-1912-4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25912030%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25912030%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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