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The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication
scientific article published in Scientific Reports
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
title
The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
main subject
Herpes simplex virus type 1
1 reference
based on heuristic
inferred from title
author
Adrian Man
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
Cornell Fraefel
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
author name string
Mark Slevin
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
Eugen Petcu
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
language of work or name
English
0 references
publication date
4 February 2019
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
published in
Scientific Reports
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
volume
9
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
page(s)
1260
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
copyright license
Creative Commons Attribution 4.0 International
start time
4 February 2019
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and regulation of the CDK5-p25(nck5a) complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of cyclin-dependent kinases by p21
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Internal ribosome entry sites (IRESs): reality and use.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdk5 phosphorylates p53 and regulates its activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuronal cell cycle: the neuron itself and its circumstances
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the p53-p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant adeno-associated viral vector production and purification.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Live visualization of herpes simplex virus type 1 compartment dynamics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of total and cytoplasmic mRNA reveals global regulation by nuclear retention and miRNAs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41598-018-37989-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transactivation of herpes simplex virus type 1 immediate-early gene expression by virion-associated factors is blocked by an inhibitor of cyclin-dependent protein kinases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30718749
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/S41598-018-37989-3
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
PMC publication ID
6362106
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
PubMed publication ID
30718749
1 reference
stated in
Europe PubMed Central
PMC publication ID
6362106
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30718749%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
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