(Q61908582)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

review article

1 reference

title

Mutant insulin receptors in syndromes of insulin resistance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

author name string

O'Rahilly S

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

language of work or name

English

0 references

publication date

1 January 1996

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

Bailliere's clinical endocrinology and metabolism

17 October 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

page(s)

97-122

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

A 3-basepair in-frame deletion (delta Leu999) in exon 17 of the insulin receptor gene in a family with insulin resistance

17 October 2019

cites work

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7 January 2021

Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features

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7 January 2021

Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues

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7 January 2021

Partial and total lipodystrophy: changes in circulating sugar, free fatty acids, insulin and growth hormone following the administration of glucose and of insulin.

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7 January 2021

A receptor-mediated pathway for cholesterol homeostasis

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7 January 2021

Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.

1 reference

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7 January 2021

Oncogenes and signal transduction

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7 January 2021

Robert Feulgen Prize Lecture 1993. The journey of the insulin receptor into the cell: from cellular biology to pathophysiology

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7 January 2021

Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance.

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7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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7 January 2021

Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity

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7 January 2021

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes

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7 January 2021

Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia

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7 January 2021

Acanthosis Nigricans, insulin action, and hyperandrogenism: clinical, histological, and biochemical findings.

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7 January 2021

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

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7 January 2021

A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose.

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7 January 2021

Insulin resistance in essential hypertension

1 reference

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7 January 2021

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

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7 January 2021

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

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7 January 2021

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

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7 January 2021

Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects

1 reference

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7 January 2021

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

1 reference

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7 January 2021

Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus.

1 reference

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7 January 2021

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

1 reference

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7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

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7 January 2021

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

1 reference

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7 January 2021

Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance

1 reference

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7 January 2021

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

1 reference

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7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

1 reference

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7 January 2021

Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered

1 reference

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7 January 2021

Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms

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7 January 2021

Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing

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7 January 2021

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism.

1 reference

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7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

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7 January 2021

Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia

1 reference

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7 January 2021

Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.

1 reference

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7 January 2021

A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface

1 reference

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7 January 2021

Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance

1 reference

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7 January 2021

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

1 reference

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7 January 2021

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

1 reference

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7 January 2021

Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

An in-frame insertion in exon 3 and a nonsense mutation in exon 2 of the insulin receptor gene associated with severe insulin resistance in a patient with Rabson-Mendenhall syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Defects in human insulin receptor gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

On the paradox of insulin-induced hyperandrogenism in insulin-resistant states

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Leprechaunism and homozygous nonsense mutation in the insulin receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

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7 January 2021

Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Acanthosis nigricans: a cutaneous marker of tissue resistance to insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

1 reference

7 January 2021

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

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7 January 2021

Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

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7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Leu 193 mutation in the cysteine rich region of the insulin receptor inhibits the cleavage of the insulin receptor precursor but not insulin binding

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

An assessment of human insulin receptor phosphorylation and exogenous kinase activity following deletion of 69 residues from the carboxyl-terminus of the receptor beta-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Patients with lipodystrophic diabetes mellitus of the Seip-Berardinelli type, express normal insulin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Molecular analysis of insulin receptor gene in Werner's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Deletion of exon 3 of the insulin receptor gene in a kindred with a familial form of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

Ligand-binding properties of the two isoforms of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0950-351X%2896%2980330-2

7 January 2021

10.1016/S0950-351X(96)80330-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

1 reference