(Q62736578)

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Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission-blocking efficacy

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scholarly article

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Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission-blocking efficacy (English)

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Schistosoma mansoni

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schistosomiasis

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inferred from title

object named as

Florian Marks

27

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28

object named as

Steven G Reed

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author name string

Weidong Zhang

1

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Adebayo J Molehin

2

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Juan U Rojo

3

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Justin Sudduth

4

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Pramodh K Ganapathy

5

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Eunjee Kim

6

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Arif J Siddiqui

7

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Jasmin Freeborn

8

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Souad R Sennoune

9

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Jordan May

10

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Samra Lazarus

11

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Catherine Nguyen

12

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Whitni K Redman

13

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Gul Ahmad

14

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Workineh Torben

15

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Souvik Karmakar

16

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Loc Le

17

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Kameswara R Kottapalli

18

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Pratibha Kottapalli

19

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Roman F Wolf

20

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James F Papin

21

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David Carey

22

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Sean A Gray

23

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Jenn D Bergthold

24

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Raymond T Damian

25

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Bryan T Mayer

26

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Darrick Carter

29

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Afzal A Siddiqui

30

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language of work or name

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publication date

August 2018

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Annals of the New York Academy of Sciences

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1425

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1

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38-51

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The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Life span of parasite in schistosomiasis patients

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Comparison of the FeKal CON-Trate system with the formalin-ethyl acetate technique for detection of intestinal parasites

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Schistosomiasis mansoni in baboons. The effect of surgical transfer of adult Schistosoma mansoni upon subsequent challenge infection

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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A statistical approach to schistosome population dynamics and estimation of the life-span of Schistosoma mansoni in man.

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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A statistically defined endpoint titer determination method for immunoassays.

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Immune responses to the radiation-attenuated schistosome vaccine: what can we learn from knock-out mice?

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Schistosome male-female interaction: induction of germ-cell differentiation

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Proteins exposed at the adult schistosome surface revealed by biotinylation

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Experimental vaccines in animal models for schistosomiasis

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Protective and antifecundity effects of Sm-p80-based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Sm-p80-based DNA vaccine made in a human use approved vector VR1020 protects against challenge infection with Schistosoma mansoni in mouse

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Role of antibodies in Sm-p80-mediated protection against Schistosoma mansoni challenge infection in murine and nonhuman primate models

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Preclinical prophylactic efficacy testing of Sm-p80-based vaccine in a nonhuman primate model of Schistosoma mansoni infection and immunoglobulin G and E responses to Sm-p80 in human serum samples from an area where schistosomiasis is endemic

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Large-scale gene function analysis with the PANTHER classification system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Schistosomiasis

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Human schistosomiasis

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Schistosomiasis control: praziquantel forever?

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Immuno-evasive tactics by schistosomes identify an effective allergy preventative

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Development of the Brazilian Anti Schistosomiasis Vaccine Based on the Recombinant Fatty Acid Binding Protein Sm14 Plus GLA-SE Adjuvant

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults.

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Workshop report: Schistosomiasis vaccine clinical development and product characteristics.

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

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Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Calpain research for drug discovery: challenges and potential

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https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Sm-p80-Based Schistosomiasis Vaccine: Preparation for Human Clinical Trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Quantitative assessment of the impact of partially protective anti-schistosomiasis vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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The evolving schistosomiasis agenda 2007-2017-Why we are moving beyond morbidity control toward elimination of transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Developing a mathematical model for the evaluation of the potential impact of a partially efficacious vaccine on the transmission dynamics of Schistosoma mansoni in human communities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Elimination of schistosomiasis: the tools required

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

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Sm-p80-based vaccine trial in baboons: efficacy when mimicking natural conditions of chronic disease, praziquantel therapy, immunization, and Schistosoma mansoni re-encounter

1 reference

https://pubmed.ncbi.nlm.nih.gov/30133707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/NYAS.13942

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