(Q63018119)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Cancer genomics: from discovery science to personalized medicine (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

main subject

personalized medicine

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

3

P Andrew Futreal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Lynda Chin

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

English

0 references

publication date

1 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

297-303

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383744%20AND%20SRC:MED&resulttype=core&format=json

Mutation of the PIK3CA gene in ovarian and breast cancer

24 January 2020

cites work

1 reference

12 December 2020

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12 December 2020

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An integrated genomic analysis of human glioblastoma multiforme

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Essential role for oncogenic Ras in tumour maintenance

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12 December 2020

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

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12 December 2020

FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Drug-sensitive FGFR2 mutations in endometrial carcinoma

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Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT

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The PI3K pathway as drug target in human cancer

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12 December 2020

American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

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Translating insights from the cancer genome into clinical practice

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Somatic activation of KIT in distinct subtypes of melanoma

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12 December 2020

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

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Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

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12 December 2020

The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease

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12 December 2020

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

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12 December 2020

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

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12 December 2020

Essential role for nuclear PTEN in maintaining chromosomal integrity

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12 December 2020

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

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12 December 2020

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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12 December 2020

PI3K and mTOR inhibitors: a new generation of targeted anticancer agents

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12 December 2020

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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12 December 2020

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

12 December 2020

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

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12 December 2020

High frequency of mutations of the PIK3CA gene in human cancers

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12 December 2020

Targeting RAS signalling pathways in cancer therapy

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12 December 2020

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

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12 December 2020

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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12 December 2020

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

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12 December 2020

Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

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12 December 2020

Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem

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12 December 2020

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

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12 December 2020

IDH1 and IDH2 mutations in gliomas

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12 December 2020

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

1 reference

12 December 2020

ARID1A mutations in endometriosis-associated ovarian carcinomas

1 reference

12 December 2020

Mechanism of activation of a human oncogene

1 reference

12 December 2020

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

1 reference

12 December 2020

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

1 reference

12 December 2020

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

12 December 2020

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

1 reference

12 December 2020

A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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12 December 2020

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

1 reference

12 December 2020

KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.

1 reference

12 December 2020

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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12 December 2020

Lung cancer: intragenic ERBB2 kinase mutations in tumours

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12 December 2020

PIKing the right patient

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12 December 2020

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

1 reference

12 December 2020

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

1 reference

12 December 2020

A census of human cancer genes

1 reference

12 December 2020