(Q64108654)

English

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway

scholarly article by Huaiqing Luo et al published 2019 in Frontiers in Pharmacology

In more languages

Statements

scholarly article

0 references

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway (English)

0 references

0 references

0 references

Alzheimer's disease

1 reference

based on heuristic

inferred from title

cognitive deficit

1 reference

based on heuristic

inferred from title

author name string

Huaiqing Luo

1

0 references

Yang Xiang

2

0 references

Xiangping Qu

3

0 references

Huijun Liu

4

0 references

Chi Liu

5

0 references

Guangyi Li

6

0 references

Li Han

7

0 references

Xiaoqun Qin

8

0 references

language of work or name

0 references

publication date

2019

0 references

Frontiers in Pharmacology

0 references

10

0 references

395

0 references

copyright license

Creative Commons Attribution 4.0 International

16 April 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6477031/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trk receptors: roles in neuronal signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum inflammatory proteins and cognitive decline in older persons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: The Honolulu-Asia Aging Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global prevalence of dementia: a Delphi consensus study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interplay between inflammation and neurodegeneration in CNS disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into brain BDNF function in normal aging and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forecasting the global burden of Alzheimer’s disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection of apelin and its signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review: systemic inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic changes of peritoneal macrophages and subpopulations during ulcerative colitis to metastasis of colorectal carcinoma in a mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmitter mediation of the anxiolytic action of apelin-13 in male mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of apelin-13 in novel object recognition memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive remission: a novel objective for the treatment of major depression?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pro-inflammatory cytokines in Alzheimer's disease].

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transient insulin system dysfunction in newborn rat brain followed by neonatal intracerebroventricular administration of streptozotocin could be accompanied by a labile cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hippocampus is a Critical Site Mediating Antidepressant-like Activity of Apelin-13 in Rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,3,7-Trihydroxyxanthone, derived from Polygalae Radix, a herbal medicine, stimulates the expression of neurotrophic factors in rat astrocyte primary cultures via cAMP- and ERK-dependent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protective effect of betulinic acid on microvascular responsivity and protein expression in alzheimer disease induced by cerebral micro-injection of beta-amyloid and streptozotocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective role of Apelin-13 on amyloid β25-35-induced memory deficit; Involvement of autophagy and apoptosis process

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and neurodegeneration: chronicity matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/31040784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FPHAR.2019.00395

0 references

0 references

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q64108654&oldid=2029702291"